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CD55 antibody (Complement Decay-Accelerating Factor) (AA 35-135)

Details for Product anti-CD55 Antibody No. ABIN395177, Supplier: Login to see
Antigen
  • Daf
  • Daf-GPI
  • Daf1
  • GPI-DAF
  • CR
  • CROM
  • DAF
  • TC
  • AI323748
  • Cd55b
  • Daf-TM
  • TM-DAF
Alternatives
anti-Human CD55 antibody for Immunohistochemistry (Paraffin-embedded Sections)
Epitope
AA 35-135
16
15
7
6
6
5
5
4
4
4
3
3
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
296
35
7
6
5
4
3
1
Host
Mouse
225
89
8
7
6
4
2
Clonality (Clone)
Monoclonal ()
Conjugate
This CD55 antibody is un-conjugated
49
45
25
10
4
3
3
3
2
2
1
1
1
1
1
Application
Western Blotting (WB)
231
140
63
63
43
36
35
21
11
5
5
4
3
2
2
1
1
1
Supplier
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Immunogen DAF (NP_000565, 35 a.a. ~ 135 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 1G3
Isotype IgG1 kappa
Specificity DAF (NP_000565, 35 a.a. ~ 135 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name DAF (CD55 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 41400 DA
Gene ID 12406
NCBI Accession NP_000565
Research Area Cell Structure
Pathways Complement System
Application Notes Western blot = 1:500-1000
Comment

Background: This gene encodes a protein involved in the regulation of the complement cascade. The encoded glycoprotein is also known as the decay-accelerating factor (DAF), binding of DAF to complement proteins accelerates their decay, disrupting the cascade and preventing damage to host cells. Antigens present on the DAF glycoprotein constitute the Cromer blood group system (CROM). Two alternatively spliced transcripts encoding different proteins have been identified. The predominant transcript encodes a membrane-bound protein expressed on cells exposed to plasma component proteins but an alternatively spliced transcript produces a soluble protein present at much lower levels. Additional, alternatively spliced transcript variants have been described, but their biological validity has not been determined.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-CD55 antibody (Complement Decay-Accelerating Factor) (AA 35-135) (ABIN395177) DAF monoclonal antibody (M01), clone 1G3 Western Blot analysis of DAF expression in H...
Immunohistochemistry (IHC) image for anti-CD55 antibody (Complement Decay-Accelerating Factor) (AA 35-135) (ABIN395177) anti-Complement Decay-Accelerating Factor (CD55) (AA 35-135) antibody (Image 2)
Background publications Romero, Friel, Velez Edwards et al.: "A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM)." in: American journal of obstetrics and gynecology, Vol. 203, Issue 4, pp. 361.e1-361.e30, 2010 (PubMed).

Gustafsson, Andersson, Hu et al.: "Adenovirus 11p downregulates CD46 early in infection." in: Virology, Vol. 405, Issue 2, pp. 474-82, 2010 (PubMed).

Romero, Velez Edwards, Kusanovic et al.: "Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes." in: American journal of obstetrics and gynecology, Vol. 202, Issue 5, pp. 431.e1-34, 2010 (PubMed).

Han, Lan, Park et al.: "Polymorphisms in innate immunity genes and risk of childhood leukemia." in: Human immunology, Vol. 71, Issue 7, pp. 727-30, 2010 (PubMed).

Rajaraman, Brenner, Neta et al.: "Risk of meningioma and common variation in genes related to innate immunity." in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 19, Issue 5, pp. 1356-61, 2010 (PubMed).