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Junctional Adhesion Molecule 2 (JAM2) (AA 29-299) antibody

Details for Product No. ABIN395190, Supplier: Login to see
Antigen
  • JAM2
  • cd322
  • jam-b
  • jamb
  • pro245
  • ve-jam
  • vejam
  • jam2
  • sb:cb1002
  • im:7155552
  • sc:d0813
  • si:ch211-160b11.5
  • LOC100227766
  • 1110002N23Rik
  • 2410030G21Rik
  • 2410167M24Rik
  • JAM-2
  • JAM-B
  • Jcam2
  • VE-JAM
  • C21orf43
  • CD322
  • JAMB
  • PRO245
  • VEJAM
Epitope
AA 29-299
17
17
9
9
4
4
3
2
2
2
1
1
1
1
1
1
1
Reactivity
Human
110
17
8
4
4
2
1
Host
Mouse
77
29
10
1
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
12
12
12
4
4
4
Application
Western Blotting (WB)
92
74
23
11
2
1
1
1
1
1
Supplier
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Immunogen JAM2 (AAH17779, 29 a.a. ~ 299 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 1G4
Isotype IgG1 kappa
Specificity JAM2 (AAH17779, 29 a.a. ~ 299 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name JAM2 (JAM2 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 33207 DA
Gene ID 12406
Research Area Cell Structure
Pathways
Application Notes Western blot = 1:500-1000
Comment

Background: Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is localized in the tight junctions between high endothelial cells. It acts as an adhesive ligand for interacting with a variety of immune cell types and may play a role in lymphocyte homing to secondary lymphoid organs.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Junctional Adhesion Molecule 2 (JAM2) (AA 29-299) antibody (ABIN395190) JAM2 monoclonal antibody (M01), clone 1G4 Western Blot analysis of JAM2 expression in...
Immunohistochemistry (IHC) image for anti-Junctional Adhesion Molecule 2 (JAM2) (AA 29-299) antibody (ABIN395190) anti-Junctional Adhesion Molecule 2 (JAM2) (AA 29-299) antibody (Image 2)
Background publications Need, Attix, McEvoy et al.: "A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB." in: Human molecular genetics, Vol. 18, Issue 23, pp. 4650-61, 2009 (PubMed).

Ueki, Iwasawa, Ishikawa et al.: "Expression of junctional adhesion molecules on the human lymphatic endothelium." in: Microvascular research, Vol. 75, Issue 2, pp. 269-78, 2008 (PubMed).

Weber, Fraemohs, Dejana: "The role of junctional adhesion molecules in vascular inflammation." in: Nature reviews. Immunology, Vol. 7, Issue 6, pp. 467-77, 2007 (PubMed).

Iden, Rehder, August et al.: "A distinct PAR complex associates physically with VE-cadherin in vertebrate endothelial cells." in: EMBO reports, Vol. 7, Issue 12, pp. 1239-46, 2006 (PubMed).

Mehrle, Rosenfelder, Schupp et al.: "The LIFEdb database in 2006." in: Nucleic acids research, Vol. 34, Issue Database issue, pp. D415-8, 2005 (PubMed).