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Details for Product No. ABIN395190

Junctional Adhesion Molecule 2 (JAM2) antibody

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Antigen
Synonyms
JAMB, CD322, JAM-B, VEJAM, PRO245, VE-JAM, C21orf43, 1110002N23Rik, 2410030G21Rik, 2410167M24Rik, JAM-2, Jcam2, JAM2, cd322, jam-b, jamb, pro245, ve-jam, vejam, jam2, sb:cb1002, im:7155552, sc:d0813,  ... show more
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN395190
Quantity 0.1 mg
Price
450.00 $   Plus shipping costs $45.00
Shipping to
Availability Will be delivered in 2 to 3 Business Days
Immunogen JAM2 (AAH17779, 29 a.a. ~ 299 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 1G4
Isotype IgG1 kappa
Specificity JAM2 (AAH17779, 29 a.a. ~ 299 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name JAM2
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 33207 DA
Gene ID 12406
Research Area Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000 Immunohistochemistry ~~ 1.5ug/ml
Comment

Background: Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is localized in the tight junctions between high endothelial cells. It acts as an adhesive ligand for interacting with a variety of immune cell types and may play a role in lymphocyte homing to secondary lymphoid organs.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Mehrle, Rosenfelder, Schupp et al.: "The LIFEdb database in 2006." in: Nucleic acids research, Vol. 34, Issue Database issue, pp. D415-8, 2005 (PubMed).

Iden, Rehder, August et al.: "A distinct PAR complex associates physically with VE-cadherin in vertebrate endothelial cells." in: EMBO reports, Vol. 7, Issue 12, pp. 1239-46, 2006 (PubMed).

Weber, Fraemohs, Dejana: "The role of junctional adhesion molecules in vascular inflammation." in: Nature reviews. Immunology, Vol. 7, Issue 6, pp. 467-77, 2007 (PubMed).

Ueki, Iwasawa, Ishikawa et al.: "Expression of junctional adhesion molecules on the human lymphatic endothelium." in: Microvascular research, Vol. 75, Issue 2, pp. 269-78, 2008 (PubMed).

Need, Attix, McEvoy et al.: "A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB." in: Human molecular genetics, Vol. 18, Issue 23, pp. 4650-61, 2009 (PubMed).

Alternatives for antigen "Junctional Adhesion Molecule 2 (JAM2)", type "Antibodies"
Hosts (16), (12), (6), (5)
Reactivities (30), (12), (3), (1), (1)
Applications (28), (14), (10), (7), (5), (3), (2), (2), (1)
Conjugates (2), (2)
Epitopes (4), (3), (2), (2), (2), (1), (1), (1), (1)
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