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Kallikrein 10 antibody (KLK10) (AA 167-277)

Details for Product anti-KLK10 Antibody No. ABIN395210, Supplier: Log in to see
Antigen
  • 2300002A13Rik
  • KLK10
  • NES1
  • PRSSL1
Alternatives
anti-Human Kallikrein 10 antibody for Western Blotting
Epitope
AA 167-277
17
13
8
5
4
4
4
3
2
2
1
1
Reactivity
Human
91
13
13
Host
Mouse
71
19
1
Clonality (Clone)
Monoclonal ()
Conjugate
This Kallikrein 10 antibody is un-conjugated
9
9
8
3
3
3
1
1
1
1
1
1
1
1
1
Application
Immunofluorescence (IF), Western Blotting (WB)
68
47
13
11
8
7
4
3
2
1
1
Supplier
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Supplier Product No.
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Immunogen KLK10 (NP_002767, 167 a.a. ~ 277 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 1G8
Isotype IgG1 lambda
Specificity KLK10 (NP_002767, 167 a.a. ~ 277 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification Purified
Alternative Name KLK10 (KLK10 Antibody Abstract)
Background Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its encoded protein is secreted and may play a role in suppression of tumorigenesis in breast and prostate cancers. Alternate splicing of this gene results in multiple transcript variants encoding the same protein.
Synonyms: NES1, PRSSL1 kallikrein 10
Molecular Weight 30138 DA
Gene ID 5655
NCBI Accession NP_002767
Research Area Cancer, Cell Structure
Pathways Complement System
Application Notes Western blot = 1:500-1000
Comment

Background: Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its encoded protein is secreted and may play a role in suppression of tumorigenesis in breast and prostate cancers. Alternate splicing of this gene results in multiple transcript variants encoding the same protein.

Restrictions For Research Use only
Concentration 1 mg/ml
Buffer Phosphate buffered saline, pH 7.2
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Kallikrein 10 antibody (KLK10) (AA 167-277) (ABIN395210) Immunofluorescence of monoclonal antibody to KLK10 on A-431 cell (antibody concentrat...
Immunohistochemistry (IHC) image for anti-Kallikrein 10 antibody (KLK10) (AA 167-277) (ABIN395210) anti-Kallikrein 10 (KLK10) (AA 167-277) antibody (Image 2)
Background publications Batra, Tan, OMara, Zammit, Nagle, Clements, Kedda, Spurdle: "Kallikrein-related peptidase 10 (KLK10) expression and single nucleotide polymorphisms in ovarian cancer survival." in: International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, Vol. 20, Issue 4, pp. 529-36, 2010

Klein, Halldén, Cronin, Ploner, Wiklund, Bjartell, Stattin, Xu, Scardino, Offit, Vickers, Grönberg, Lilja: "Blood biomarker levels to aid discovery of cancer-related single-nucleotide polymorphisms: kallikreins and prostate cancer." in: Cancer prevention research (Philadelphia, Pa.), Vol. 3, Issue 5, pp. 611-9, 2010

Papageorgis, Lambert, Ozturk, Gao, Pan, Manne, Alekseyev, Thiagalingam, Abdolmaleky, Lenburg, Thiagalingam: "Smad signaling is required to maintain epigenetic silencing during breast cancer progression." in: Cancer research, Vol. 70, Issue 3, pp. 968-78, 2010

Lu, Hsieh, Lu, Wu, Chen, Lo, Wu, Chou, Huang, Chang: "Aberrant DNA methylation profile and frequent methylation of KLK10 and OXGR1 genes in hepatocellular carcinoma." in: Genes, chromosomes & cancer, Vol. 48, Issue 12, pp. 1057-68, 2009

Sardana, Diamandis: "The kallikrein family of proteins as urinary biomarkers for the detection of prostate cancer." in: Clinical biochemistry, Vol. 42, Issue 13-14, pp. 1483-6, 2009