|+1 404 474 4654|
|+1 888 205 9894 (TF)|
Kallikrein 10 (KLK10) antibody
|Synonyms||ACO, HSRNASPH, NES1, PRSSL1, TLSP, PRSS20, MGC33060, KLK-L6, 2300002A13Rik, KLK10|
Alternatives ELISA, Immunofluorescence (IF), Western Blotting (WB)
|5 references available|
|Quantity||0.05 mg (1 mg/ml)|
|Price||450.00 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Immunogen||KLK10 (NP_002767, 167 a.a. ~ 277 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K|
|Description||Other names: NES1, PRSSL1 kallikrein 10|
|Characteristics||Purified Mouse Monoclonal Antibody (Mab)|
|Specificity||KLK10 (NP_002767, 167 a.a. ~ 277 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Molecular Weight||30138 DA|
Background: Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its encoded protein is secreted and may play a role in suppression of tumorigenesis in breast and prostate cancers. Alternate splicing of this gene results in multiple transcript variants encoding the same protein.
|Application Notes||ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000 Immunofluorescence|
|Buffer||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles|
|Research Area||Cancer, Cell Structure|
|Restrictions||For Research Use only|
Sardana, Diamandis: "The kallikrein family of proteins as urinary biomarkers for the detection of prostate cancer." in: Clinical biochemistry, Vol. 42, Issue 13-14, pp. 1483-6, 2009 (PubMed).
Lu, Hsieh, Lu et al.: "Aberrant DNA methylation profile and frequent methylation of KLK10 and OXGR1 genes in hepatocellular carcinoma." in: Genes, chromosomes & cancer, Vol. 48, Issue 12, pp. 1057-68, 2009 (PubMed).
Papageorgis, Lambert, Ozturk et al.: "Smad signaling is required to maintain epigenetic silencing during breast cancer progression." in: Cancer research, Vol. 70, Issue 3, pp. 968-78, 2010 (PubMed).
Klein, Halldén, Cronin et al.: "Blood biomarker levels to aid discovery of cancer-related single-nucleotide polymorphisms: kallikreins and prostate cancer." in: Cancer prevention research (Philadelphia, Pa.), Vol. 3, Issue 5, pp. 611-9, 2010 (PubMed).
Batra, Tan, OMara et al.: "Kallikrein-related peptidase 10 (KLK10) expression and single nucleotide polymorphisms in ovarian cancer survival." in: International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, Vol. 20, Issue 4, pp. 529-36, 2010 (PubMed).
|Hosts||Rabbit (32), Goat (1), Mouse (1)|
|Reactivities||Human (33), Cow (Bovine) (18), Mouse (Murine) (18), Rat (Rattus) (18)|
|Applications||Western Blotting (WB) (19), ELISA (17), Immunofluorescence (IF) (15), Immunohistochemistry (IHC) (7), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (3), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (3), Immunoelectron Microscopy (IEM) (1), Immunoprecipitation (IP) (1)|
|Conjugates||Biotin (3), FITC (2), HRP (2), Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), Gold (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy5.5 (1), PE,Cy7 (1)|
|Epitopes||N-Term (2), Center (1), Internal Region (1)|