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BIN1 antibody (Bridging Integrator 1) (AA 355-455)

Details for Product anti-BIN1 Antibody No. ABIN395214, Supplier: Log in to see
Antigen
  • bin1
  • MGC53185
  • amph2
  • amphl
  • sh3p9
  • MGC76187
  • cb57
  • zgc:86701
  • BIN1
  • AMPH2
  • AMPHL
  • SH3P9
  • ALP-1
  • Amphl
  • BRAMP-2
Epitope
AA 355-455
18
11
7
7
3
3
3
2
2
2
2
1
1
1
Reactivity
Human
81
42
26
3
2
2
1
1
1
1
Host
Mouse
41
29
14
Clonality (Clone)
Monoclonal ()
Conjugate
This BIN1 antibody is un-conjugated
2
2
2
2
2
2
1
1
1
Application
Western Blotting (WB)
72
40
29
9
9
6
6
5
3
2
2
2
1
Supplier
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Immunogen BIN1 (NP_004296, 355 a.a. ~ 455 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 1H1
Isotype IgG1 kappa
Specificity BIN1 (NP_004296, 355 a.a. ~ 455 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name BIN1 (BIN1 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 64699 DA
Gene ID 12406
NCBI Accession NP_004296
Research Area Cancer, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynanim, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in ten transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-BIN1 antibody (Bridging Integrator 1) (AA 355-455) (ABIN395214) BIN1 monoclonal antibody (M01), clone 1H1 Western Blot analysis of BIN1 expression in...
Background publications Biffi, Anderson, Desikan et al.: "Genetic variation and neuroimaging measures in Alzheimer disease." in: Archives of neurology, Vol. 67, Issue 6, pp. 677-85, 2010 (PubMed).

Seshadri, Fitzpatrick, Ikram et al.: "Genome-wide analysis of genetic loci associated with Alzheimer disease." in: JAMA : the journal of the American Medical Association, Vol. 303, Issue 18, pp. 1832-40, 2010 (PubMed).

Yoshida, Kato, Yokoi et al.: "Association of genetic variants with hemorrhagic stroke in Japanese individuals." in: International journal of molecular medicine, Vol. 25, Issue 4, pp. 649-56, 2010 (PubMed).

Hong, Smyth, Gao et al.: "BIN1 localizes the L-type calcium channel to cardiac T-tubules." in: PLoS biology, Vol. 8, Issue 2, pp. e1000312, 2010 (PubMed).

Claeys, Maisonobe, Böhm et al.: "Phenotype of a patient with recessive centronuclear myopathy and a novel BIN1 mutation." in: Neurology, Vol. 74, Issue 6, pp. 519-21, 2010 (PubMed).