Bridging Integrator 1 (BIN1) antibody

Details for Product No. ABIN395214
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Antigen
Synonyms AMPH2, AMPHL, SH3P9, ALP-1, Amphl, BRAMP-2, bin1, MGC53185, amph2, amphl, sh3p9, MGC76187, cb57, zgc:86701, BIN1
Reactivity
Human
(55), (37), (28), (13), (12), (4), (3)
Host
Mouse
(32), (21), (4)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(44), (21), (12), (10), (8), (8), (5), (3), (2), (2), (2), (2), (1)
Pubmed 5 references available
Catalog no. ABIN395214
Quantity 0.1 mg
Price
450.00 $   Plus shipping costs $45.00
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Immunogen BIN1 (NP_004296, 355 a.a. ~ 455 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 1H1
Isotype IgG1 kappa
Specificity BIN1 (NP_004296, 355 a.a. ~ 455 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name BIN1
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 64699 DA
Gene ID 12406
UniProt NP_004296
Research Area Cancer, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynanim, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in ten transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Bridging Integrator 1 (BIN1) antibody BIN1 monoclonal antibody (M01), clone 1H1 Western Blot analysis of BIN1 expression in HeLa NE.
Background publications Claeys, Maisonobe, Böhm et al.: "Phenotype of a patient with recessive centronuclear myopathy and a novel BIN1 mutation." in: Neurology, Vol. 74, Issue 6, pp. 519-21, 2010 (PubMed).

Hong, Smyth, Gao et al.: "BIN1 localizes the L-type calcium channel to cardiac T-tubules." in: PLoS biology, Vol. 8, Issue 2, pp. e1000312, 2010 (PubMed).

Yoshida, Kato, Yokoi et al.: "Association of genetic variants with hemorrhagic stroke in Japanese individuals." in: International journal of molecular medicine, Vol. 25, Issue 4, pp. 649-56, 2010 (PubMed).

Seshadri, Fitzpatrick, Ikram et al.: "Genome-wide analysis of genetic loci associated with Alzheimer disease." in: JAMA : the journal of the American Medical Association, Vol. 303, Issue 18, pp. 1832-40, 2010 (PubMed).

Biffi, Anderson, Desikan et al.: "Genetic variation and neuroimaging measures in Alzheimer disease." in: Archives of neurology, Vol. 67, Issue 6, pp. 677-85, 2010 (PubMed).

Hosts (32), (21), (4)
Reactivities (55), (37), (28), (13), (12), (4), (3)
Applications (44), (21), (12), (10), (8), (8), (5), (3), (2), (2), (2), (2), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (3), (2), (2), (2), (2), (1), (1)
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