Fragile Histidine Triad (FHIT) (AA 1-111) antibody

Details for Product No. ABIN395220
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Antigen
Synonyms AP3Aase, FRA3B, AW045638, Fra14A2
Epitope
AA 1-111
(18), (11), (7), (3), (3), (2), (1), (1), (1), (1), (1)
Reactivity
Human
(100), (29), (29), (24), (12), (12), (12)
Host
Mouse
(89), (12)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(4), (4), (4), (2), (2), (2), (2), (2), (2), (2), (2)
Application
ELISA, Western Blotting (WB)
(54), (45), (41), (22), (20), (13), (5)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN395220
450.00 $
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Immunogen FHIT (AAH32336, 1 a.a. ~ 111 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 1H2
Isotype IgG Mix kappa
Specificity FHIT (AAH32336, 1 a.a. ~ 111 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name FHIT
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 16858 DA
Gene ID 12406
Research Area Cancer, Metabolism, Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000
Comment

Background: This gene, a member of the histidine triad gene family, encodes a diadenosine 5',5'''-P1,P3-triphosphate hydrolase involved in purine metabolism. The gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts of this gene. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. Alternatively spliced transcript variants have been found for this gene.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Fragile Histidine Triad (FHIT) (AA 1-111) antibody Detection limit for recombinant GST tagged FHIT is approximately 3 ng/mL as a capture antibody.
Background publications Okamoto, Ogawa, Nowak et al.: "Genomic profiling of adult acute lymphoblastic leukemia by single nucleotide polymorphism oligonucleotide microarray and comparison to pediatric acute lymphoblastic leukemia." in: Haematologica, Vol. 95, Issue 9, pp. 1481-8, 2010 (PubMed).

Tsao, Atramentova: "[Genetic and epigenetic changes of FHIT gene in patients with esophageal cancer]." in: T͡Sitologii͡a i genetika, Vol. 43, Issue 6, pp. 40-4, 2010 (PubMed).

Lin, Wang, Huang et al.: "[The relationship between FHIT and WWOX expression and clinicopathological features in hepatocellular carcinoma]." in: Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology, Vol. 18, Issue 5, pp. 357-60, 2010 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Yin, Wang, Sun et al.: "Homozygous deletion but not mutation of exons 5 and 8 of the fragile histidine triad (FHIT) gene is associated with features of differentiated thyroid carcinoma." in: Annals of clinical and laboratory science, Vol. 40, Issue 3, pp. 267-72, 2010 (PubMed).

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