HABP2 antibody (Hyaluronan Binding Protein 2) (AA 105-205)

Details for Product anti-HABP2 Antibody No. ABIN395235, Supplier: Log in to see
Antigen
  • HABP2
  • habp2
  • FSAP
  • HABP
  • HGFAL
  • PHBP
  • Fsap
  • Habp
  • Phbp
  • AI035669
  • hyaluronan binding protein 2
  • hyaluronic acid binding protein 2
  • HABP2
  • habp2
  • LOC100223786
  • Habp2
Epitope
AA 105-205
6
5
4
4
2
2
2
2
2
1
1
1
1
1
1
Reactivity
Human
40
17
15
4
4
4
3
1
1
1
1
Host
Mouse
33
7
Clonality (Clone)
Monoclonal ()
Application
ELISA
34
12
8
5
4
2
2
1
1
Options
Supplier
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Supplier Product No.
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Immunogen HABP2 (NP_004123, 105 a.a. ~ 205 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 1H4
Isotype IgG2a kappa
Specificity HABP2 (NP_004123, 105 a.a. ~ 205 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name HABP2 (HABP2 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 62672 DA
Gene ID 12406
NCBI Accession NP_004123
Research Area Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml
Comment

Background: The protein encoded by this gene is an extracellular serine protease that binds hyaluronic acid and is involved in cell adhesion. The encoded protein is synthesized as a single chain, but then undergoes an autoproteolytic event to form the functional heterodimer. Further autoproteolysis leads to smaller, inactive peptides. This protease is known to cleave urinary plasminogen activator, coagulation factor VII, and the alpha and beta chains of fibrinogen, but not prothrombin, plasminogen, or the gamma chain of fibrinogen. Two transcript variants encoding different isoforms have been found for this gene.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
ELISA image for anti-Hyaluronan Binding Protein 2 (HABP2) (AA 105-205) antibody (ABIN395235) Detection limit for recombinant GST tagged HABP2 is approximately 1 ng/mL as a captur...
Background publications Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Lanktree, Johansen, Anand, Davis, Miller, Yusuf, Hegele, ,: "Genetic variation in hyaluronan metabolism loci is associated with plasma plasminogen activator inhibitor-1 concentration." in: Blood, Vol. 116, Issue 12, pp. 2160-3, 2010 (PubMed).

Antón, González-Conejero, Roldán, Quiroga, Sánchez-Vega, Corral, Vicente, Mezzano: "Study of 18 functional hemostatic polymorphisms in mucocutaneous bleeding disorders." in: Annals of hematology, Vol. 89, Issue 11, pp. 1147-54, 2010 (PubMed).

Mambetsariev, Mirzapoiazova, Mambetsariev, Sammani, Lennon, Garcia, Singleton: "Hyaluronic Acid binding protein 2 is a novel regulator of vascular integrity." in: Arteriosclerosis, thrombosis, and vascular biology, Vol. 30, Issue 3, pp. 483-90, 2010 (PubMed).

Talmud, Drenos, Shah, Shah, Palmen, Verzilli, Gaunt, Pallas, Lovering, Li, Casas, Sofat, Kumari, Rodriguez, Johnson, Newhouse, Dominiczak, Samani, Caulfield, Sever, Stanton, Shields, Padmanabhan et al.: "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. ..." in: American journal of human genetics, Vol. 85, Issue 5, pp. 628-42, 2009 (PubMed).

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