Hyaluronan Binding Protein 2 (HABP2) (AA 105-205) antibody

Details for Product No. ABIN395235
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Antigen
Synonyms HABP2, habp2, FSAP, HABP, HGFAL, PHBP, Fsap, Habp, Phbp, AI035669
Epitope
AA 105-205
(4), (2), (2), (2), (2), (2), (1), (1)
Reactivity
Human
(30), (21), (17), (1)
Host
Mouse
(27), (4)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA
(20), (10), (7), (4), (3), (2), (2)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN395235
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Immunogen HABP2 (NP_004123, 105 a.a. ~ 205 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 1H4
Isotype IgG2a kappa
Specificity HABP2 (NP_004123, 105 a.a. ~ 205 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name HABP2
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 62672 DA
Gene ID 12406
NCBI Accession NP_004123
Research Area Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml
Comment

Background: The protein encoded by this gene is an extracellular serine protease that binds hyaluronic acid and is involved in cell adhesion. The encoded protein is synthesized as a single chain, but then undergoes an autoproteolytic event to form the functional heterodimer. Further autoproteolysis leads to smaller, inactive peptides. This protease is known to cleave urinary plasminogen activator, coagulation factor VII, and the alpha and beta chains of fibrinogen, but not prothrombin, plasminogen, or the gamma chain of fibrinogen. Two transcript variants encoding different isoforms have been found for this gene.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Hyaluronan Binding Protein 2 (HABP2) (AA 105-205) antibody Detection limit for recombinant GST tagged HABP2 is approximately 1 ng/mL as a capture antibody.
Background publications Talmud, Drenos, Shah et al.: "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip." in: American journal of human genetics, Vol. 85, Issue 5, pp. 628-42, 2009 (PubMed).

Mambetsariev, Mirzapoiazova, Mambetsariev et al.: "Hyaluronic Acid binding protein 2 is a novel regulator of vascular integrity." in: Arteriosclerosis, thrombosis, and vascular biology, Vol. 30, Issue 3, pp. 483-90, 2010 (PubMed).

Antón, González-Conejero, Roldán et al.: "Study of 18 functional hemostatic polymorphisms in mucocutaneous bleeding disorders." in: Annals of hematology, Vol. 89, Issue 11, pp. 1147-54, 2010 (PubMed).

Lanktree, Johansen, Anand et al.: "Genetic variation in hyaluronan metabolism loci is associated with plasma plasminogen activator inhibitor-1 concentration." in: Blood, Vol. 116, Issue 12, pp. 2160-3, 2010 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

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