Potassium Voltage-Gated Channel, Isk-Related Family, Member 1 (KCNE1) (Met13) antibody

Details for Product No. ABIN395293
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Antigen
Synonyms isk, jlns, mink, jlns2, xkcne1, KCNE1, ISK, JLNS, JLNS2, LQT2/5, LQT5, MinK, Isk, m, minK, IsK, nmf190
Epitope
Met13
(9), (7), (6), (2), (1), (1)
Reactivity
Human
(52), (18), (18), (12), (12), (12)
Host
Mouse
(38), (13)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA
(39), (22), (13), (10), (10), (5), (4), (3), (3), (2), (1), (1)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN395293
450.00 $
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Immunogen KCNE1 (AAH36452, 1 a.a. ~ 106 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 2A6
Isotype IgG2a kappa
Specificity KCNE1 (AAH36452, 1 a.a. ~ 106 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name KCNE1
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 14675 DA
Gene ID 12406
Research Area Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml
Comment

Background: The product of this gene belongs to the potassium channel KCNE family. Potassium ion channels are essential to many cellular functions and show a high degree of diversity, varying in their electrophysiologic and pharmacologic properties. This gene encodes a transmembrane protein known to associate with the product of the KVLQT1 gene to form the delayed rectifier potassium channel. Mutation in this gene are associated with both Jervell and Lange-Nielsen and Romano-Ward forms of long-QT syndrome. Alternatively spliced transcript variants encoding the same protein have been identified.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Potassium Voltage-Gated Channel, Isk-Related Family, Member 1 (KCNE1) (Met13) antibody Detection limit for recombinant GST tagged KCNE1 is approximately 3 ng/mL as a capture antibody.
Background publications Albert, MacRae, Chasman et al.: "Common variants in cardiac ion channel genes are associated with sudden cardiac death." in: Circulation. Arrhythmia and electrophysiology, Vol. 3, Issue 3, pp. 222-9, 2010 (PubMed).

Yokoyama, Urashima, Ohkido et al.: "L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms." in: Nephron. Clinical practice, Vol. 115, Issue 4, pp. c237-43, 2010 (PubMed).

Lvov, Gage, Berrios et al.: "Identification of a protein-protein interaction between KCNE1 and the activation gate machinery of KCNQ1." in: The Journal of general physiology, Vol. 135, Issue 6, pp. 607-18, 2010 (PubMed).

Siem, Fagerheim, Jonsrud et al.: "Causes of hearing impairment in the Norwegian paediatric cochlear implant program." in: International journal of audiology, Vol. 49, Issue 8, pp. 596-605, 2010 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

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