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Potassium Voltage-Gated Channel, Isk-Related Family, Member 1 (KCNE1) (Met13) antibody

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Synonyms isk, jlns, mink, jlns2, xkcne1, KCNE1, ISK, JLNS, JLNS2, LQT2/5, LQT5, MinK, Isk, m, minK, IsK, nmf190
(13), (7), (5), (5), (3), (2), (1), (1), (1)
(55), (23), (21), (13)
(43), (11)
Clonality (Clone)
Monoclonal ()
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
(34), (13), (12), (11), (7), (4), (3), (2), (1), (1), (1), (1)
Pubmed 5 references available
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Quantity 0.1 mg
Shipping to United States ( )
Availability Will be delivered in 8 to 11 Business Days
Immunogen KCNE1 (AAH36452, 1 a.a. ~ 106 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 2A6
Isotype IgG2a kappa
Specificity KCNE1 (AAH36452, 1 a.a. ~ 106 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name KCNE1 (KCNE1 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 14675 DA
Gene ID 12406
Research Area Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml

Background: The product of this gene belongs to the potassium channel KCNE family. Potassium ion channels are essential to many cellular functions and show a high degree of diversity, varying in their electrophysiologic and pharmacologic properties. This gene encodes a transmembrane protein known to associate with the product of the KVLQT1 gene to form the delayed rectifier potassium channel. Mutation in this gene are associated with both Jervell and Lange-Nielsen and Romano-Ward forms of long-QT syndrome. Alternatively spliced transcript variants encoding the same protein have been identified.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
ELISA image for anti-Potassium Voltage-Gated Channel, Isk-Related Family, Member 1 (KCNE1) (Met13) antibody (ABIN395293) Detection limit for recombinant GST tagged KCNE1 is approximately 3 ng/mL as a captur...
Background publications Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Siem, Fagerheim, Jonsrud et al.: "Causes of hearing impairment in the Norwegian paediatric cochlear implant program." in: International journal of audiology, Vol. 49, Issue 8, pp. 596-605, 2010 (PubMed).

Lvov, Gage, Berrios et al.: "Identification of a protein-protein interaction between KCNE1 and the activation gate machinery of KCNQ1." in: The Journal of general physiology, Vol. 135, Issue 6, pp. 607-18, 2010 (PubMed).

Yokoyama, Urashima, Ohkido et al.: "L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms." in: Nephron. Clinical practice, Vol. 115, Issue 4, pp. c237-43, 2010 (PubMed).

Albert, MacRae, Chasman et al.: "Common variants in cardiac ion channel genes are associated with sudden cardiac death." in: Circulation. Arrhythmia and electrophysiology, Vol. 3, Issue 3, pp. 222-9, 2010 (PubMed).

Catalog No. ABIN395293
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