FGFR1 Oncogene Partner (FGFR1OP) antibody

Antigen: FGFR1 Oncogene Partner (FGFR1OP)

Synonyms: FOP, MGC90966, MGC117820, 4930553O10Rik, ccr6a, zgc:86782, FGFR1OP, fgfr1op, Fgfr1op, MGC132198

Clonality: Monoclonal (2B1)

Host: Mouse

Reactivity: Human

Conjugate: Un-conjugated

Application: ELISA, Western Blotting (WB)

Certificates: ISO 9001:2008

Catalog no.: ABIN395324

Additional Information

Alternative name: FGFR1OP

Gene ID: 11116

Immunogen: FGFR1OP (AAH11902, 1 a.a. ~ 380 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K

Isotype: IgG2b kappa

Clone: 2B1

Description: Other names: FOP FGFR1 oncogene partner

Characteristics: Purified Mouse Monoclonal Antibody (Mab)

Specificity: FGFR1OP (AAH11902, 1 a.a. ~ 380 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Molecular Weight: 43065 DA

Comments:

Background: This gene encodes a largely hydrophilic protein postulated to be a leucine-rich protein family member. A t(6,8)(q27,p11) chromosomal translocation, fusing this gene and the fibroblast growth factor receptor 1 (FGFR1) gene, has been found in cases of myeloproliferative disorder. The resulting chimeric protein contains the N-terminal leucine-rich region of this encoded protein fused to the catalytic domain of FGFR1. This gene is thought to play an important role in normal proliferation and differentiation of the erythroid lineage. Alternatively spliced transcript variants that encode different proteins have been identified.

Application Details

Application Notes: ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000

Purification: Purified

Buffer: Clear, colorless solution in phosphate buffered saline, pH 7.2 .

Storage: Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles

Research Area: Cell Cycle, Cell Structure

Restrictions: For Research Use only

Images

Detection limit for recombinant GST tagged FGFR1OP is approximately 0.03ng/ml as a capture antibody.

Publications

Product: Goudreault, DAmbrosio, Kean et al.: "A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein." in: Molecular & cellular proteomics : MCP, Vol. 8, Issue 1, pp. 157-71, 2009 (PubMed).

Anderson, Massey, Barrett et al.: "Investigation of Crohn's disease risk loci in ulcerative colitis further defines their molecular relationship." in: Gastroenterology, Vol. 136, Issue 2, pp. 523-9.e3, 2009 (PubMed).

Davila, Froeling, Tan et al.: "New genetic associations detected in a host response study to hepatitis B vaccine." in: Genes and immunity, Vol. 11, Issue 3, pp. 232-8, 2010 (PubMed).

Rose, Behm, Drgon et al.: "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score." in: Molecular medicine (Cambridge, Mass.), Vol. 16, Issue 7-8, pp. 247-53, 2010 (PubMed).

Quan, Ren, Xiang et al.: "Genome-wide association study for vitiligo identifies susceptibility loci at 6q27 and the MHC." in: Nature genetics, Vol. 42, Issue 7, pp. 614-8, 2010 (PubMed).