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Aldo-Keto Reductase Family 1, Member B10 (Aldose Reductase) (AKR1B10) (AA 76-144) antibody

Details for Product No. ABIN395347, Supplier: Log in to see
Antigen
  • AKR
  • AKR1B10
  • AKR1B11
  • AKR1B12
  • ALDRLn
  • ARL-1
  • ARL1
  • HIS
  • HSI
  • 2310005E10Rik
  • Akr1b16
Epitope
AA 76-144
13
12
11
10
7
6
6
4
3
3
2
2
1
1
Reactivity
Human
73
17
15
1
1
Host
Mouse
44
15
14
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
3
3
3
3
2
2
1
Application
Western Blotting (WB)
66
39
14
12
12
3
1
1
1
1
1
Supplier
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Immunogen AKR1B10 (NP_064695, 76 a.a. ~ 144 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 2B3
Isotype IgG1 kappa
Specificity AKR1B10 (NP_064695, 76 a.a. ~ 144 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name AKR1B10 (AKR1B10 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 36021 DA
Gene ID 12406
NCBI Accession NP_064695
Research Area Cell Structure
Pathways
Application Notes Western blot = 1:500-1000
Comment

Background: This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member can efficiently reduce aliphatic and aromatic aldehydes, and it is less active on hexoses. It is highly expressed in adrenal gland, small intestine, and colon, and may play an important role in liver carcinogenesis.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Aldo-Keto Reductase Family 1, Member B10 (Aldose Reductase) (AKR1B10) (AA 76-144) antibody (ABIN395347) AKR1B10 monoclonal antibody (M03), clone 2B3. Western Blot analysis of AKR1B10 expres...
Background publications Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Kropotova, Tychko, Zinoveva et al.: "[Downregulation of AKR1B10 gene expression in colorectal cancer]." in: Molekuliarnaia biologiia, Vol. 44, Issue 2, pp. 243-50, 2010 (PubMed).

Heringlake, Hofdmann, Fiebeler et al.: "Identification and expression analysis of the aldo-ketoreductase1-B10 gene in primary malignant liver tumours." in: Journal of hepatology, Vol. 52, Issue 2, pp. 220-7, 2010 (PubMed).

Ravindranath, Mong, Ananthakrishnan et al.: "Novel role for aldose reductase in mediating acute inflammatory responses in the lung." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 183, Issue 12, pp. 8128-37, 2009 (PubMed).

Talmud, Drenos, Shah et al.: "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. ..." in: American journal of human genetics, Vol. 85, Issue 5, pp. 628-42, 2009 (PubMed).