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Oligophrenin 1 antibody (OPHN1) (AA 641-735)

Details for Product anti-OPHN1 Antibody No. ABIN395392, Supplier: Login to see
Antigen
  • MGC68856
  • zgc:92603
  • OPHN1
  • mrx60
  • opn1
  • ARHGAP41
  • MRX60
  • OPN1
  • C130037N19Rik
  • Opn1
Epitope
AA 641-735
2
2
1
Reactivity
Human
12
6
6
Host
Mouse
7
5
Clonality (Clone)
Monoclonal ()
Conjugate
This Oligophrenin 1 antibody is un-conjugated
1
Application
ELISA, Western Blotting (WB)
10
8
5
1
1
Supplier
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Immunogen OPHN1 (NP_002538, 641 a.a. ~ 735 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 2B9
Isotype IgG2a kappa
Specificity OPHN1 (NP_002538, 641 a.a. ~ 735 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name OPHN1 (OPHN1 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 91641 DA
Gene ID 12406
NCBI Accession NP_002538
Research Area Cell Signaling, Cell Structure
Pathways
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000
Comment

Background: This gene encodes a Rho-GTPase-activating protein that promotes GTP hydrolysis of Rho subfamily members. Rho proteins are important mediators of intracellular signal transduction, which affects cell migration and cell morphogenesis. Mutations in this gene are responsible for OPHN1-related X-linked mental retardation with cerebellar hypoplasia and distinctive facial dysmorhphism.

Restrictions For Research Use only
Concentration 1 mg/ml
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
ELISA image for anti-Oligophrenin 1 antibody (OPHN1) (AA 641-735) (ABIN395392) Detection limit for recombinant GST tagged OPHN1 is approximately 0.3 ng/mL as a capt...
Background publications Piton, Gauthier, Hamdan et al.: "Systematic resequencing of X-chromosome synaptic genes in autism spectrum disorder and schizophrenia." in: Molecular psychiatry, Vol. 16, Issue 8, pp. 867-80, 2011 (PubMed).

Takefuji, Asano, Mori et al.: "Mutation of ARHGAP9 in patients with coronary spastic angina." in: Journal of human genetics, Vol. 55, Issue 1, pp. 42-9, 2010 (PubMed).

Zhang, Zheng, Zhang et al.: "[Anassociation study between OPHN1 gene rs492933 polymorphism and mental retardation in children of the Qinba Mountain region.]." in: Yi chuan = Hereditas / Zhongguo yi chuan xue hui bian ji, Vol. 30, Issue 10, pp. 1307-11, 2008 (PubMed).

Madrigal, Rodríguez-Revenga, Badenas et al.: "Deletion of the OPHN1 gene detected by aCGH." in: Journal of intellectual disability research : JIDR, Vol. 52, Issue Pt 3, pp. 190-4, 2008 (PubMed).

Barbe, Lundberg, Oksvold et al.: "Toward a confocal subcellular atlas of the human proteome." in: Molecular & cellular proteomics : MCP, Vol. 7, Issue 3, pp. 499-508, 2008 (PubMed).