Oligophrenin 1 (OPHN1) antibody

Antigen: Oligophrenin 1 (OPHN1)

Synonyms: OPN1, MRX60, MGC6513, C130037N19Rik, Opn1, MGC68856, zgc:92603, OPHN1, opn1, mrx60, MGC145878

Clonality: Monoclonal (2B9)

Host: Mouse

Reactivity: Human

Conjugate: Un-conjugated

Application: ELISA, Western Blotting (WB)

Certificates: ISO 9001:2008

Catalog no.: ABIN395392

Additional Information

Alternative name: OPHN1

Gene ID: 4983

UniProt: NP_002538

Immunogen: OPHN1 (NP_002538, 641 a.a. ~ 735 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K

Isotype: IgG2a kappa

Clone: 2B9

Description: Other names: OPN1 oligophrenin 1

Characteristics: Purified Mouse Monoclonal Antibody (Mab)

Specificity: OPHN1 (NP_002538, 641 a.a. ~ 735 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Molecular Weight: 91641 DA

Comments:

Background: This gene encodes a Rho-GTPase-activating protein that promotes GTP hydrolysis of Rho subfamily members. Rho proteins are important mediators of intracellular signal transduction, which affects cell migration and cell morphogenesis. Mutations in this gene are responsible for OPHN1-related X-linked mental retardation with cerebellar hypoplasia and distinctive facial dysmorhphism.

Application Details

Application Notes: ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000

Concentration: 1 mg/ml

Purification: Purified

Buffer: Clear, colorless solution in phosphate buffered saline, pH 7.2 .

Storage: Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles

Research Area: Cell Signaling, Cell Structure

Restrictions: For Research Use only

Images

Detection limit for recombinant GST tagged OPHN1 is approximately 0.3ng/ml as a capture antibody.

Publications

Product: Barbe, Lundberg, Oksvold et al.: "Toward a confocal subcellular atlas of the human proteome." in: Molecular & cellular proteomics : MCP, Vol. 7, Issue 3, pp. 499-508, 2008 (PubMed).

Madrigal, Rodríguez-Revenga, Badenas et al.: "Deletion of the OPHN1 gene detected by aCGH." in: Journal of intellectual disability research : JIDR, Vol. 52, Issue Pt 3, pp. 190-4, 2008 (PubMed).

Zhang, Zheng, Zhang et al.: "[Anassociation study between OPHN1 gene rs492933 polymorphism and mental retardation in children of the Qinba Mountain region.]." in: Yi chuan = Hereditas / Zhongguo yi chuan xue hui bian ji, Vol. 30, Issue 10, pp. 1307-11, 2008 (PubMed).

Takefuji, Asano, Mori et al.: "Mutation of ARHGAP9 in patients with coronary spastic angina." in: Journal of human genetics, Vol. 55, Issue 1, pp. 42-9, 2010 (PubMed).

Piton, Gauthier, Hamdan et al.: "Systematic resequencing of X-chromosome synaptic genes in autism spectrum disorder and schizophrenia." in: Molecular psychiatry, Vol. 16, Issue 8, pp. 867-80, 2011 (PubMed).