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Chemokine (C-X-C Motif) Receptor 5 (CXCR5) (AA 1-56) antibody

Details for Product No. ABIN395397
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Antigen
Synonyms BLR1, CRL1, CD185, MDR15, Blr1, CXC-R5, CXCR-5, Gpcr6, NLR
Epitope
AA 1-56
(8), (7), (3), (2), (2), (2), (1), (1), (1)
Reactivity
Human
(51), (22), (21), (17), (17)
Host
Mouse
(47), (4), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB)
(28), (14), (14), (9), (6), (3), (2), (1), (1), (1)
Pubmed 5 references available
Quantity 0.1 mg
Options
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Catalog No. ABIN395397
450.00 $
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Immunogen BLR1 (NP_001707, 1 a.a. ~ 56 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 2C1
Isotype IgG2a kappa
Specificity BLR1 (NP_001707, 1 a.a. ~ 56 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name BLR1
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 41955 DA
Gene ID 12406
UniProt NP_001707
Research Area Cell Structure, Cancer
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000
Comment

Background: This gene was identified as a gene specifically expressed in Burkitt's lymphoma and lymphatic tissues. The protein encoded by this gene is predicted to be a seven transmembrane G protein- coupled receptor and belongs to the CXC chemokine receptor family. BLC, a B-lymphocyte chemoattractant, was identified to be a specific ligand for this receptor. Studies of this gene and its mouse conterpart strongly suggest the essential function of this gene in B cell migration and localization within specific anatomic compartments, such as follicles in lymph nodes as well as in spleen. Two alternatively spliced variants of this gene exist.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Chemokine (C-X-C Motif) Receptor 5 (CXCR5) (AA 1-56) antibody Detection limit for recombinant GST tagged BLR1 is approximately 0.03 ng/mL as a capture antibody.
Background publications Singh, Singh, Singh et al.: "Clinical and biological significance of CXCR5 expressed by prostate cancer specimens and cell lines." in: International journal of cancer. Journal international du cancer, Vol. 125, Issue 10, pp. 2288-95, 2009 (PubMed).

Talmud, Drenos, Shah et al.: "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip." in: American journal of human genetics, Vol. 85, Issue 5, pp. 628-42, 2009 (PubMed).

Lee, Shiao, Wu et al.: "Serum BLC/CXCL13 concentrations and renal expression of CXCL13/CXCR5 in patients with systemic lupus erythematosus and lupus nephritis." in: The Journal of rheumatology, Vol. 37, Issue 1, pp. 45-52, 2009 (PubMed).

El Haibi, Sharma, Singh et al.: "PI3Kp110-, Src-, FAK-dependent and DOCK2-independent migration and invasion of CXCL13-stimulated prostate cancer cells." in: Molecular cancer, Vol. 9, pp. 85, 2010 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Validation Images
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