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Zyxin (ZYX) (AA 1-573) antibody

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Synonyms BcDNA:LD06023, CG32018, DLim-1, DmLIM-1, Dmel\\CG32018, Lim102EF, ZYX102, Zyx102, Zyx102EF, lim, zyx102, zyxin, zgc:171680, ZYX, zyx, MGC145270, ESP-2, HED-2, 9530098H06Rik, R75157
AA 1-573
(8), (8), (8), (8), (7), (6), (6), (3), (2), (1), (1), (1), (1), (1)
(89), (18), (16), (5), (4), (2), (2), (1), (1), (1), (1), (1)
(56), (19), (14)
Clonality (Clone)
Monoclonal ()
(5), (4), (2), (1), (1), (1), (1)
Western Blotting (WB)
(78), (49), (17), (14), (13), (12), (6), (5), (3), (2), (1), (1)
Pubmed 5 references available
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Quantity 0.1 mg
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Availability Will be delivered in 8 to 11 Business Days
Immunogen ZYX (AAH08743, 1 a.a. ~ 573 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 2C10-4A7
Isotype IgG1 kappa
Specificity ZYX (AAH08743, 1 a.a. ~ 573 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name ZYX (ZYX Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 61277 DA
Gene ID 12406
Research Area Cell Signaling, Cell Structure
Application Notes Western blot = 1:500-1000

Background: Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. Alternative splicing results in multiple transcript variants that encode the same isoform.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Zyxin (ZYX) (AA 1-573) antibody (ABIN395405) Western blot analysis of ZYX over-expressed 293 cell line, cotransfected with ZYX Val...
Immunohistochemistry (IHC) image for anti-Zyxin (ZYX) (AA 1-573) antibody (ABIN395405) anti-Zyxin (ZYX) (AA 1-573) antibody (Image 2)
Background publications Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Talmud, Drenos, Shah et al.: "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. ..." in: American journal of human genetics, Vol. 85, Issue 5, pp. 628-42, 2009 (PubMed).

Sun, Huiatt, Paulin et al.: "Synemin interacts with the LIM domain protein zyxin and is essential for cell adhesion and migration." in: Experimental cell research, Vol. 316, Issue 3, pp. 491-505, 2010 (PubMed).

Han, Liu, Profirovic et al.: "Zyxin is involved in thrombin signaling via interaction with PAR-1 receptor." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 23, Issue 12, pp. 4193-206, 2009 (PubMed).

Hirata, Tatsumi, Sokabe: "Mechanical forces facilitate actin polymerization at focal adhesions in a zyxin-dependent manner." in: Journal of cell science, Vol. 121, Issue Pt 17, pp. 2795-804, 2008 (PubMed).

Catalog No. ABIN395405
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