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WDR5 antibody (WD Repeat Domain 5) (AA 16-121)

Details for Product anti-WDR5 Antibody No. ABIN395423, Supplier: Log in to see
Antigen
  • zgc:56591
  • zgc:76895
  • wu:fk47f04
  • wdr5-a
  • MGC80538
  • wdr5-b
  • MGC81485
  • big-3
  • swd3
  • xwdr5
  • BIG-3
  • SWD3
  • 2410008O07Rik
  • AA408785
  • AA960360
  • Big
  • Big-3
Epitope
AA 16-121
24
16
8
4
4
4
3
3
3
2
2
2
1
1
1
1
Reactivity
Human
79
18
10
Host
Mouse
66
14
2
1
Clonality (Clone)
Monoclonal ()
Conjugate
This WDR5 antibody is un-conjugated
4
3
3
2
2
2
Application
Immunofluorescence (IF), Western Blotting (WB)
73
45
13
6
5
4
3
2
1
Supplier
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Immunogen WDR5 (NP_060058, 16 a.a. ~ 121 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 2C2
Isotype IgG2b kappa
Specificity WDR5 (NP_060058, 16 a.a. ~ 121 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name WDR5 (WDR5 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 36588 DA
Gene ID 12406
NCBI Accession NP_060058
Research Area Cell Signaling, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 7 WD repeats. Alternatively spliced transcript variants encoding the same protein have been identified.

Restrictions For Research Use only
Concentration 1 mg/ml
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-WDR5 antibody (WD Repeat Domain 5) (AA 16-121) (ABIN395423) Immunofluorescence of monoclonal antibody to WDR5 on HeLa cell (antibody concentratio...
Immunohistochemistry (IHC) image for anti-WDR5 antibody (WD Repeat Domain 5) (AA 16-121) (ABIN395423) anti-WD Repeat Domain 5 (WDR5) (AA 16-121) antibody (Image 2)
Background publications Davis, Butcher, Docherty et al.: "A three-stage genome-wide association study of general cognitive ability: hunting the small effects." in: Behavior genetics, Vol. 40, Issue 6, pp. 759-67, 2010 (PubMed).

Feng, Yonezawa, Ye et al.: "PHF8 activates transcription of rRNA genes through H3K4me3 binding and H3K9me1/2 demethylation." in: Nature structural & molecular biology, Vol. 17, Issue 4, pp. 445-50, 2010 (PubMed).

Jin, Zhao, Yi et al.: "c-Myb binds MLL through menin in human leukemia cells and is an important driver of MLL-associated leukemogenesis." in: The Journal of clinical investigation, Vol. 120, Issue 2, pp. 593-606, 2010 (PubMed).

Yates, Menon, Thompson et al.: "Regulation of HOXA2 gene expression by the ATP-dependent chromatin remodeling enzyme CHD8." in: FEBS letters, Vol. 584, Issue 4, pp. 689-93, 2010 (PubMed).

Wang, Liu, Zhong et al.: "WDR5 is essential for assembly of the VISA-associated signaling complex and virus-triggered IRF3 and NF-kappaB activation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 2, pp. 815-20, 2010 (PubMed).