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WD Repeat Domain 5 (WDR5) (AA 16-121) antibody

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Synonyms zgc:56591, zgc:76895, wu:fk47f04, wdr5-a, MGC80538, wdr5-b, MGC81485, big-3, swd3, xwdr5, BIG-3, SWD3, 2410008O07Rik, AA408785, AA960360, Big, Big-3
AA 16-121
(24), (16), (8), (4), (4), (4), (3), (3), (3), (2), (2), (1), (1), (1), (1), (1)
(79), (17), (9)
(65), (15), (2), (1)
Clonality (Clone)
Monoclonal ()
(4), (3), (3), (2), (2), (2)
Immunofluorescence (IF), Western Blotting (WB)
(73), (45), (13), (6), (5), (4), (3), (2), (1)
Pubmed 5 references available
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Quantity 0.1 mg
Shipping to United States ( )
Availability Will be delivered in 8 to 11 Business Days
Immunogen WDR5 (NP_060058, 16 a.a. ~ 121 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 2C2
Isotype IgG2b kappa
Specificity WDR5 (NP_060058, 16 a.a. ~ 121 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name WDR5 (WDR5 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 36588 DA
Gene ID 12406
NCBI Accession NP_060058
Research Area Cell Signaling, Cell Structure
Application Notes Western blot = 1:500-1000

Background: This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 7 WD repeats. Alternatively spliced transcript variants encoding the same protein have been identified.

Restrictions For Research Use only
Concentration 1 mg/ml
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-WD Repeat Domain 5 (WDR5) (AA 16-121) antibody (ABIN395423) Immunofluorescence of monoclonal antibody to WDR5 on HeLa cell (antibody concentratio...
Immunohistochemistry (IHC) image for anti-WD Repeat Domain 5 (WDR5) (AA 16-121) antibody (ABIN395423) anti-WD Repeat Domain 5 (WDR5) (AA 16-121) antibody (Image 2)
Background publications Davis, Butcher, Docherty et al.: "A three-stage genome-wide association study of general cognitive ability: hunting the small effects." in: Behavior genetics, Vol. 40, Issue 6, pp. 759-67, 2010 (PubMed).

Feng, Yonezawa, Ye et al.: "PHF8 activates transcription of rRNA genes through H3K4me3 binding and H3K9me1/2 demethylation." in: Nature structural & molecular biology, Vol. 17, Issue 4, pp. 445-50, 2010 (PubMed).

Jin, Zhao, Yi et al.: "c-Myb binds MLL through menin in human leukemia cells and is an important driver of MLL-associated leukemogenesis." in: The Journal of clinical investigation, Vol. 120, Issue 2, pp. 593-606, 2010 (PubMed).

Yates, Menon, Thompson et al.: "Regulation of HOXA2 gene expression by the ATP-dependent chromatin remodeling enzyme CHD8." in: FEBS letters, Vol. 584, Issue 4, pp. 689-93, 2010 (PubMed).

Wang, Liu, Zhong et al.: "WDR5 is essential for assembly of the VISA-associated signaling complex and virus-triggered IRF3 and NF-kappaB activation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 2, pp. 815-20, 2010 (PubMed).

Catalog No. ABIN395423
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