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Details for Product No. ABIN395423

WD Repeat Domain 5 (WDR5) antibody

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Antigen
Synonyms SWD3, BIG-3, Big, Big-3, AA408785, AA960360, 2410008O07Rik, zgc:56591, zgc:76895, wu:fk47f04, wdr5-a, MGC80538, wdr5-b, MGC81485, big-3, swd3, xwdr5
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives ELISA, Immunofluorescence (IF), Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN395423
Quantity 0.1 mg
Price
450.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen WDR5 (NP_060058, 16 a.a. ~ 121 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 2C2
Isotype IgG2b kappa
Specificity WDR5 (NP_060058, 16 a.a. ~ 121 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name WDR5
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 36588 DA
Gene ID 12406
UniProt NP_060058
Research Area Cell Signaling, Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000 Immunofluorescence
Comment

Background: This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 7 WD repeats. Alternatively spliced transcript variants encoding the same protein have been identified.

Restrictions For Research Use only
Concentration 1 mg/ml
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Wang, Liu, Zhong et al.: "WDR5 is essential for assembly of the VISA-associated signaling complex and virus-triggered IRF3 and NF-kappaB activation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 2, pp. 815-20, 2010 (PubMed).

Yates, Menon, Thompson et al.: "Regulation of HOXA2 gene expression by the ATP-dependent chromatin remodeling enzyme CHD8." in: FEBS letters, Vol. 584, Issue 4, pp. 689-93, 2010 (PubMed).

Jin, Zhao, Yi et al.: "c-Myb binds MLL through menin in human leukemia cells and is an important driver of MLL-associated leukemogenesis." in: The Journal of clinical investigation, Vol. 120, Issue 2, pp. 593-606, 2010 (PubMed).

Feng, Yonezawa, Ye et al.: "PHF8 activates transcription of rRNA genes through H3K4me3 binding and H3K9me1/2 demethylation." in: Nature structural & molecular biology, Vol. 17, Issue 4, pp. 445-50, 2010 (PubMed).

Davis, Butcher, Docherty et al.: "A three-stage genome-wide association study of general cognitive ability: hunting the small effects." in: Behavior genetics, Vol. 40, Issue 6, pp. 759-67, 2010 (PubMed).

Alternatives for antigen "WD Repeat Domain 5 (WDR5)", type "Antibodies"
Hosts (29), (11), (1)
Reactivities (36), (6), (3)
Applications (36), (21), (5), (2), (2), (2), (1)
Conjugates (1), (1)
Epitopes (11), (4), (4), (2), (2), (1), (1)
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