Glucagon (GCG) (AA 1-181) antibody

Details for Product No. ABIN395510, Supplier: Log in to see
Antigen
  • GCG
  • 9230102N17Rik
  • D330003E03
  • Eu-HMTase1
  • GLP
  • GLP1
  • KMT1D
  • mKIAA1876
  • EUHMTASE1
  • FP13812
  • bA188C12.1
  • GLP2
  • GRPP
  • GLP-1
  • Glu
  • PPG
  • gcg-A
  • gcg1
  • 9530092J08Rik
  • GLP-2
  • GATAD3
  • glucagon
  • euchromatic histone methyltransferase 1
  • euchromatic histone-lysine N-methyltransferase 1
  • glucagon-like peptide 2 receptor
  • mast cell protease 10
  • zinc finger, GATA-like protein 1
  • GCG
  • Ehmt1
  • EHMT1
  • Gcg
  • LOC100341777
  • gcg
  • Glp2r
  • Mcpt10
  • ZGLP1
Alternatives
anti-Cow (Bovine) Glucagon antibody for Radioimmunoassay
Epitope
AA 1-181
37
28
21
16
12
11
9
7
6
5
5
4
4
3
3
2
2
2
2
2
1
1
1
1
1
1
1
Reactivity
Human
298
121
106
68
17
11
8
7
6
5
5
4
4
3
2
2
2
1
1
1
1
1
1
Host
Mouse
175
108
28
13
4
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
14
7
6
4
4
4
4
3
3
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
ELISA, Western Blotting (WB)
134
128
85
82
52
39
33
24
17
13
11
9
5
4
3
3
3
3
2
1
1
1
1
1
Options
Supplier
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Supplier Product No.
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Immunogen GCG (AAH05278, 1 a.a. ~ 181 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 2D3-2B11
Isotype IgG1 kappa
Specificity GCG (AAH05278, 1 a.a. ~ 181 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name GCG (GCG Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 20909 DA
Gene ID 12406
Research Area Cell Cycle, Cell Structure
Pathways Positive Regulation of Peptide Hormone Secretion, Peptide Hormone Metabolism, cAMP Metabolic Process, Regulation of Carbohydrate Metabolic Process, Feeding Behaviour, Negative Regulation of intrinsic apoptotic Signaling
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000
Comment

Background: The protein encoded by this gene is actually a preproprotein that is cleaved into four distinct mature peptides. One of these, glucagon, is a pancreatic hormone that counteracts the glucose-lowering action of insulin by stimulating glycogenolysis and gluconeogenesis. Glucagon is a ligand for a specific G-protein linked receptor whose signalling pathway controls cell proliferation. Two of the other peptides are secreted from gut endocrine cells and promote nutrient absorption through distinct mechanisms. Finally, the fourth peptide is similar to glicentin, an active enteroglucagon.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
ELISA image for anti-Glucagon (GCG) (AA 1-181) antibody (ABIN395510) Detection limit for recombinant GST tagged GCG is approximately 0.03 ng/mL as a captu...
Background publications Jablonski, McAteer, de Bakker, Franks, Pollin, Hanson, Saxena, Fowler, Shuldiner, Knowler, Altshuler, Florez: "Common variants in 40 genes assessed for diabetes incidence and response to metformin and lifestyle intervention in the diabetes prevention program." in: Diabetes, Vol. 59, Issue 10, pp. 2672-81, 2010 (PubMed).

Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Yamaoka-Tojo, Tojo, Takahira, Matsunaga, Aoyama, Masuda, Izumi: "Elevated circulating levels of an incretin hormone, glucagon-like peptide-1, are associated with metabolic components in high-risk patients with cardiovascular disease." in: Cardiovascular diabetology, Vol. 9, pp. 17, 2010 (PubMed).

Brubaker: "Minireview: update on incretin biology: focus on glucagon-like peptide-1." in: Endocrinology, Vol. 151, Issue 5, pp. 1984-9, 2010 (PubMed).

Valsamakis, Margeli, Vitoratos, Boutsiadis, Sakkas, Papadimitriou, Al-Daghri, Botsis, Kumar, Papassotiriou, Creatsas, Mastorakos: "The role of maternal gut hormones in normal pregnancy: fasting plasma active glucagon-like peptide 1 level is a negative predictor of fetal abdomen circumference and maternal weight change." in: European journal of endocrinology / European Federation of Endocrine Societies, Vol. 162, Issue 5, pp. 897-903, 2010 (PubMed).

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