You are viewing an incomplete version of our website. Please click to reload the website as full version.

Glucagon (GCG) (AA 1-181) antibody

Details for Product No. ABIN395510, Supplier: Log in to see
Antigen
  • GCG
  • 9230102N17Rik
  • D330003E03
  • Eu-HMTase1
  • GLP
  • GLP1
  • KMT1D
  • mKIAA1876
  • EUHMTASE1
  • FP13812
  • bA188C12.1
  • GLP2
  • GRPP
  • GLP-1
  • Glu
  • PPG
  • gcg-A
  • gcg1
  • 9530092J08Rik
  • GLP-2
  • GATAD3
Epitope
AA 1-181
32
25
23
18
14
14
14
11
11
7
7
7
5
5
5
4
3
3
2
2
2
1
1
1
1
1
Reactivity
Human
306
88
83
38
10
7
3
3
2
2
1
1
1
1
1
1
1
Host
Mouse
192
86
42
14
4
1
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
19
6
5
5
4
4
2
2
1
1
1
1
1
1
1
1
1
1
1
Application
ELISA, Western Blotting (WB)
155
151
65
61
29
24
19
16
11
11
9
6
5
4
3
3
3
3
1
1
1
Supplier
Log in to see
Supplier Product No.
Log in to see
Request

Showcase your results, aid the scientific community, and receive a full refund.

Contribute a validation

Learn more

Available images

Immunogen GCG (AAH05278, 1 a.a. ~ 181 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 2D3-2B11
Isotype IgG1 kappa
Specificity GCG (AAH05278, 1 a.a. ~ 181 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name GCG (GCG Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 20909 DA
Gene ID 12406
Research Area Cell Cycle, Cell Structure
Pathways
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000
Comment

Background: The protein encoded by this gene is actually a preproprotein that is cleaved into four distinct mature peptides. One of these, glucagon, is a pancreatic hormone that counteracts the glucose-lowering action of insulin by stimulating glycogenolysis and gluconeogenesis. Glucagon is a ligand for a specific G-protein linked receptor whose signalling pathway controls cell proliferation. Two of the other peptides are secreted from gut endocrine cells and promote nutrient absorption through distinct mechanisms. Finally, the fourth peptide is similar to glicentin, an active enteroglucagon.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
ELISA image for anti-Glucagon (GCG) (AA 1-181) antibody (ABIN395510) Detection limit for recombinant GST tagged GCG is approximately 0.03 ng/mL as a captu...
Background publications Jablonski, McAteer, de Bakker et al.: "Common variants in 40 genes assessed for diabetes incidence and response to metformin and lifestyle intervention in the diabetes prevention program." in: Diabetes, Vol. 59, Issue 10, pp. 2672-81, 2010 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Yamaoka-Tojo, Tojo, Takahira et al.: "Elevated circulating levels of an incretin hormone, glucagon-like peptide-1, are associated with metabolic components in high-risk patients with cardiovascular disease." in: Cardiovascular diabetology, Vol. 9, pp. 17, 2010 (PubMed).

Brubaker: "Minireview: update on incretin biology: focus on glucagon-like peptide-1." in: Endocrinology, Vol. 151, Issue 5, pp. 1984-9, 2010 (PubMed).

Valsamakis, Margeli, Vitoratos et al.: "The role of maternal gut hormones in normal pregnancy: fasting plasma active glucagon-like peptide 1 level is a negative predictor of fetal abdomen circumference and maternal weight change." in: European journal of endocrinology / European Federation of Endocrine Societies, Vol. 162, Issue 5, pp. 897-903, 2010 (PubMed).