gamma-aminobutyric Acid (GABA) B Receptor, 1 (GABBR1) (AA 52-151) antibody

Details for Product No. ABIN395531
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Antigen
Synonyms gabbr1, GABBR1, GABA(B)R1, GABABR1, GABBR1-3, GB1, GPRC3A, dJ271M21.1.1, dJ271M21.1.2, GABAB1, GABAbR1, bM573K1.1
Epitope
AA 52-151
(23), (19), (19), (10), (8), (4), (3), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(81), (76), (51), (29), (26), (12), (12), (2), (1), (1), (1)
Host
Mouse
(78), (32), (3), (3), (1), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(4), (4), (4), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunofluorescence (IF), Western Blotting (WB)
(87), (30), (26), (20), (19), (16), (11), (2), (2), (1)
Pubmed 5 references available
Quantity 0.1 mg
Options
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Catalog No. ABIN395531
450.00 $
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Immunogen GABBR1 (AAH50532, 52 a.a. ~ 151 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 2D7
Isotype IgG2a kappa
Specificity GABBR1 (AAH50532, 52 a.a. ~ 151 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name GABBR1
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 108320 DA
Gene ID 12406
Research Area Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the mammalian central nervous system. GABA exerts its effects through ionotropic [GABA(A/C)] receptors, to produce fast synaptic inhibition, and metabotropic [GABA(B)] receptors, to produce slow, prolonged inhibitory signals. The GABA(B) receptor consists of a heterodimer of two related 7-transmembrane receptors, GABA(B) receptor 1 and GABA(B) receptor 2. The GABA(B) receptor 1 gene is mapped to chromosome 6p21.3 within the HLA class I region close to the HLA-F gene. Susceptibility loci for multiple sclerosis, epilepsy, and schizophrenia have also been mapped in this region. Alternative splicing of this gene generates multiple transcript variants.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-gamma-aminobutyric Acid (GABA) B Receptor, 1 (GABBR1) (AA 52-151) antibody Immunofluorescence of monoclonal antibody to GABBR1 on HeLa cell (antibody concentration 10 µg/mL). Western blot analysis of GABBR1 over-expressed 293 cell line, cotransfected with GABBR1 Validated Chimera RNAi used as specificity and loading control.
anti-gamma-aminobutyric Acid (GABA) B Receptor, 1 (GABBR1) (AA 52-151) antibody (2) anti-gamma-aminobutyric Acid (GABA) B Receptor, 1 (GABBR1) (AA 52-151) antibody (Image 2)
Background publications Sombekke, Arteta, van de Wiel et al.: "Analysis of multiple candidate genes in association with phenotypes of multiple sclerosis." in: Multiple sclerosis (Houndmills, Basingstoke, England), Vol. 16, Issue 6, pp. 652-9, 2010 (PubMed).

Rose, Behm, Drgon et al.: "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score." in: Molecular medicine (Cambridge, Mass.), Vol. 16, Issue 7-8, pp. 247-53, 2010 (PubMed).

Saus, Brunet, Armengol et al.: "Comprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients." in: Journal of psychiatric research, Vol. 44, Issue 14, pp. 971-8, 2010 (PubMed).

Pinheiro, Bulik, Thornton et al.: "Association study of 182 candidate genes in anorexia nervosa." in: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, Vol. 153B, Issue 5, pp. 1070-80, 2010 (PubMed).

Oblak, Gibbs, Blatt: "Decreased GABA(B) receptors in the cingulate cortex and fusiform gyrus in autism." in: Journal of neurochemistry, Vol. 114, Issue 5, pp. 1414-23, 2010 (PubMed).

Validation Images
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