Fatty Acid Desaturase 1 (FADS1) (AA 1-100) antibody

Details for Product No. ABIN395544
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Antigen
Synonyms D5D, FADS6, FADSD5, LLCDL1, TU12, D5FAD, 0710001O03Rik, A930006B21Rik, AI317215, DSD
Epitope
AA 1-100
(9), (4), (4), (3), (3), (2), (1), (1)
Reactivity
Human
(46), (20), (19), (16), (14), (13), (1), (1)
Host
Mouse
(27), (14), (6)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(37), (18), (10), (10), (7), (3), (1), (1), (1)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN395544
450.00 $
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Immunogen (NP_037534, 1 a.a. ~ 100 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 2D9
Isotype IgG2a kappa
Specificity (NP_037534, 1 a.a. ~ 100 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name FADS1
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 51964 DA
Gene ID 12406
NCBI Accession NP_037534
Research Area Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: The protein encoded by this gene is a member of the fatty acid desaturase (FADS) gene family. Desaturase enzymes regulate unsaturation of fatty acids through the introduction of double bonds between defined carbons of the fatty acyl chain. FADS family members are considered fusion products composed of an N-terminal cytochrome b5-like domain and a C-terminal multiple membrane-spanning desaturase portion, both of which are characterized by conserved histidine motifs. This gene is clustered with family members FADS1 and FADS2 at 11q12-q13.1, this cluster is thought to have arisen evolutionarily from gene duplication based on its similar exon/intron organization.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Fatty Acid Desaturase 1 (FADS1) (AA 1-100) antibody monoclonal antibody (M04), clone 2D9. Western Blot analysis of expression in Hela NE. Detection limit for recombinant GST tagged FADS1 is approximately 0.03 ng/mL as a capture antibody.
anti-Fatty Acid Desaturase 1 (FADS1) (AA 1-100) antibody (2) anti-Fatty Acid Desaturase 1 (FADS1) (AA 1-100) antibody (Image 2)
Background publications Mathias, Vergara, Gao et al.: "FADS genetic variants and omega-6 polyunsaturated fatty acid metabolism in a homogeneous island population." in: Journal of lipid research, Vol. 51, Issue 9, pp. 2766-74, 2010 (PubMed).

Fontaine-Bisson, Renström, Rolandsson et al.: "Evaluating the discriminative power of multi-trait genetic risk scores for type 2 diabetes in a northern Swedish population." in: Diabetologia, Vol. 53, Issue 10, pp. 2155-62, 2010 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Eijgelsheim, Newton-Cheh, Sotoodehnia et al.: "Genome-wide association analysis identifies multiple loci related to resting heart rate." in: Human molecular genetics, Vol. 19, Issue 19, pp. 3885-94, 2010 (PubMed).

Zietemann, Kröger, Enzenbach et al.: "Genetic variation of the FADS1 FADS2 gene cluster and n-6 PUFA composition in erythrocyte membranes in the European Prospective Investigation into Cancer and Nutrition-Potsdam study." in: The British journal of nutrition, Vol. 104, Issue 12, pp. 1748-59, 2010 (PubMed).

Validation Images
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