Fatty Acid Desaturase 1 (FADS1) antibody

Antigen: Fatty Acid Desaturase 1 (FADS1)

Synonyms: D5D, TU12, FADS6, FADSD5, LLCDL1, FLJ38956, FLJ90273, DSD, AI317215, MGC37858, 0710001O03Rik, A930006B21Rik, D5FAD

Clonality: Monoclonal (2D9)

Host: Mouse

Reactivity: Human

Conjugate: Un-conjugated

Application: ELISA, Western Blotting (WB)

Certificates: ISO 9001:2008

Catalog no.: ABIN395544

Additional Information

Alternative name: FADS1

Gene ID: 3992

UniProt: NP_037534

Immunogen: (NP_037534, 1 a.a. ~ 100 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K

Isotype: IgG2a kappa

Clone: 2D9

Description: Other names: BC269730_2, D5D, FADS6, FADSD5, FLJ90273, LLCDL1, TU12 fatty acid desaturase 1

Characteristics: Purified Mouse Monoclonal Antibody (Mab)

Specificity: (NP_037534, 1 a.a. ~ 100 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Molecular Weight: 51964 DA

Comments:

Background: The protein encoded by this gene is a member of the fatty acid desaturase (FADS) gene family. Desaturase enzymes regulate unsaturation of fatty acids through the introduction of double bonds between defined carbons of the fatty acyl chain. FADS family members are considered fusion products composed of an N-terminal cytochrome b5-like domain and a C-terminal multiple membrane-spanning desaturase portion, both of which are characterized by conserved histidine motifs. This gene is clustered with family members FADS1 and FADS2 at 11q12-q13.1, this cluster is thought to have arisen evolutionarily from gene duplication based on its similar exon/intron organization.

Application Details

Application Notes: ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000

Purification: Purified

Buffer: Clear, colorless solution in phosphate buffered saline, pH 7.2 .

Storage: Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles

Research Area: Cell Structure

Restrictions: For Research Use only

Images

monoclonal antibody (M04), clone 2D9. Western Blot analysis of expression in Hela NE ( Cat # L013V3 ). Detection limit for recombinant GST tagged FADS1 is approximately 0.03ng/ml as a capture antibody.

anti-Fatty Acid Desaturase 1 (FADS1) antibody (Image 2)

Publications

Product: Mathias, Vergara, Gao et al.: "FADS genetic variants and omega-6 polyunsaturated fatty acid metabolism in a homogeneous island population." in: Journal of lipid research, Vol. 51, Issue 9, pp. 2766-74, 2010 (PubMed).

Fontaine-Bisson, Renström, Rolandsson et al.: "Evaluating the discriminative power of multi-trait genetic risk scores for type 2 diabetes in a northern Swedish population." in: Diabetologia, Vol. 53, Issue 10, pp. 2155-62, 2010 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Eijgelsheim, Newton-Cheh, Sotoodehnia et al.: "Genome-wide association analysis identifies multiple loci related to resting heart rate." in: Human molecular genetics, Vol. 19, Issue 19, pp. 3885-94, 2010 (PubMed).

Zietemann, Kröger, Enzenbach et al.: "Genetic variation of the FADS1 FADS2 gene cluster and n-6 PUFA composition in erythrocyte membranes in the European Prospective Investigation into Cancer and Nutrition-Potsdam study." in: The British journal of nutrition, Vol. 104, Issue 12, pp. 1748-59, 2010 (PubMed).