F11 Receptor (F11R) (AA 1-300) antibody

Details for Product No. ABIN395554
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Antigen
Synonyms CD321, JAM, JAM1, JAMA, JCAM, KAT, PAM-1, 9130004G24, AA638916, ESTM33, JAM-1, JAM-A, Jcam, Jcam1, Ly106, Jam1
Epitope
AA 1-300
(14), (7), (5), (5), (3), (1), (1), (1), (1)
Reactivity
Human
(68), (36), (20), (14), (14), (12), (1), (1), (1)
Host
Mouse
(36), (26), (16), (4), (2)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(5), (5), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(41), (35), (14), (12), (12), (10), (8), (8), (7), (4), (4), (3), (2), (2), (1)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN395554
450.00 $
Plus shipping costs $45.00

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  • +1 404 474 4654
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Immunogen F11R (AAH01533, 1 a.a. ~ 300 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 2E3-1C8
Isotype IgG1 kappa
Specificity F11R (AAH01533, 1 a.a. ~ 300 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name F11R
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 32583 DA
Gene ID 12406
Research Area Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is an important regulator of tight junction assembly in epithelia. In addition, the encoded protein can act as (1) a receptor for reovirus, (2) a ligand for the integrin LFA1, involved in leukocyte transmigration, and (3) a platelet receptor. Multiple 5' alternatively spliced variants, encoding the same protein, have been identified but their biological validity has not been established.

Restrictions For Research Use only
Concentration 1mg/ml 08186
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-F11 Receptor (F11R) (AA 1-300) antibody F11R monoclonal antibody (M01), clone 2E3-1C8 Western Blot analysis of F11R expression in HepG2 on formalin-fixed paraffin-embedded human breast cancer tissue (antibody concentration 1 µg/mL).
anti-F11 Receptor (F11R) (AA 1-300) antibody (2) anti-F11 Receptor (F11R) (AA 1-300) antibody (Image 2)
Background publications Ogasawara, Kojima, Go et al.: "Induction of JAM-A during differentiation of human THP-1 dendritic cells." in: Biochemical and biophysical research communications, Vol. 389, Issue 3, pp. 543-9, 2009 (PubMed).

Talmud, Drenos, Shah et al.: "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip." in: American journal of human genetics, Vol. 85, Issue 5, pp. 628-42, 2009 (PubMed).

Davila, Froeling, Tan et al.: "New genetic associations detected in a host response study to hepatitis B vaccine." in: Genes and immunity, Vol. 11, Issue 3, pp. 232-8, 2010 (PubMed).

Stellos, Langer, Gnerlich et al.: "Junctional adhesion molecule A expressed on human CD34+ cells promotes adhesion on vascular wall and differentiation into endothelial progenitor cells." in: Arteriosclerosis, thrombosis, and vascular biology, Vol. 30, Issue 6, pp. 1127-36, 2010 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Validation Images
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