F11 Receptor (F11R) antibody

Antigen: F11 Receptor (F11R)

Clonality: Monoclonal (2E3-1C8)

Host: Mouse

Reactivity: Human

Conjugate: Un-conjugated

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)

Certificates: ISO 9001:2008

Catalog no.: ABIN395554

Additional Information

Alternative name: F11R

Gene ID: 50848

Immunogen: F11R (AAH01533, 1 a.a. ~ 300 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K

Isotype: IgG1 kappa

Clone: 2E3-1C8

Description: Other names: JAM, JAM1, JAMA, JAM1, JCAM, KAT, PAM1F11 receptor

Characteristics: Purified Mouse Monoclonal Antibody (Mab)

Specificity: F11R (AAH01533, 1 a.a. ~ 300 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Molecular Weight: 32583 DA

Comments:

Background: Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is an important regulator of tight junction assembly in epithelia. In addition, the encoded protein can act as (1) a receptor for reovirus, (2) a ligand for the integrin LFA1, involved in leukocyte transmigration, and (3) a platelet receptor. Multiple 5' alternatively spliced variants, encoding the same protein, have been identified but their biological validity has not been established.

Application Details

Application Notes: ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000 Immunohistochemistry ~~ 1.5ug/ml

Concentration: 1mg/ml 08186

Purification: Purified

Buffer: Clear, colorless solution in phosphate buffered saline, pH 7.2 .

Storage: Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles

Research Area: Cell Structure

Restrictions: For Research Use only

Images

F11R monoclonal antibody (M01), clone 2E3-1C8 Western Blot analysis of F11R expression in HepG2 ( Cat # L019V1 ). Immunoperoxidase of monoclonal antibody to F11R ( Cat # AT1974a ) on formalin-fixed paraffin-embedded human breast cancer tissue. [antibody concentration 1ug/ml]

anti-F11 Receptor (F11R) antibody (Image 2)

Publications

Product: Ogasawara, Kojima, Go et al.: "Induction of JAM-A during differentiation of human THP-1 dendritic cells." in: Biochemical and biophysical research communications, Vol. 389, Issue 3, pp. 543-9, 2009 (PubMed).

Talmud, Drenos, Shah et al.: "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip." in: American journal of human genetics, Vol. 85, Issue 5, pp. 628-42, 2009 (PubMed).

Davila, Froeling, Tan et al.: "New genetic associations detected in a host response study to hepatitis B vaccine." in: Genes and immunity, Vol. 11, Issue 3, pp. 232-8, 2010 (PubMed).

Stellos, Langer, Gnerlich et al.: "Junctional adhesion molecule A expressed on human CD34+ cells promotes adhesion on vascular wall and differentiation into endothelial progenitor cells." in: Arteriosclerosis, thrombosis, and vascular biology, Vol. 30, Issue 6, pp. 1127-36, 2010 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).