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Details for Product No. ABIN395555

Glyceraldehyde-3-Phosphate Dehydrogenase, Spermatogenic (GAPDHS) antibody

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Antigen
Synonyms Gapds, Gapd-s, GAPD2, GAPDS, HSD-35, GAPDH-2, cb350, fb71f08, fk58c09, g3pdh, gapdh, gapdh-2, gapds, wu:fb71f08, wu:fk58c09, zgc:76908, GAPDHS
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN395555
Quantity 0.1 mg
Price
450.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen GAPDS (AAH36373, 1 a.a. ~ 409 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 2E3-2E10
Isotype IgG1 kappa
Specificity GAPDS (AAH36373, 1 a.a. ~ 409 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name GAPDS
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 44501 DA
Gene ID 12406
Research Area Metabolism, Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000 Immunohistochemistry ~~ 1.5ug/ml
Comment

Background: This gene encodes a protein belonging to the glyceraldehyde-3-phosphate dehydrogenase family of enzymes that play an important role in carbohydrate metabolism. Like its somatic cell counterpart, this sperm-specific enzyme functions in a nicotinamide adenine dinucleotide-dependent manner to remove hydrogen and add phosphate to glyceraldehyde 3-phosphate to form 1,3-diphosphoglycerate. During spermiogenesis, this enzyme may play an important role in regulating the switch between different energy-producing pathways, and it is required for sperm motility and male fertility.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Yatsenko, Roy, Chen et al.: "Non-invasive genetic diagnosis of male infertility using spermatozoal RNA: KLHL10 mutations in oligozoospermic patients impair homodimerization." in: Human molecular genetics, Vol. 15, Issue 23, pp. 3411-9, 2006 (PubMed).

Bertram, McQueen, Mullin et al.: "Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database." in: Nature genetics, Vol. 39, Issue 1, pp. 17-23, 2006 (PubMed).

Ewing, Chu, Elisma et al.: "Large-scale mapping of human protein-protein interactions by mass spectrometry." in: Molecular systems biology, Vol. 3, pp. 89, 2007 (PubMed).

Shchutskaya, Elkina, Kuravsky et al.: "Investigation of glyceraldehyde-3-phosphate dehydrogenase from human sperms." in: Biochemistry. Biokhimii͡a, Vol. 73, Issue 2, pp. 185-91, 2008 (PubMed).

Corneveaux, Myers, Allen et al.: "Association of CR1, CLU and PICALM with Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals." in: Human molecular genetics, Vol. 19, Issue 16, pp. 3295-301, 2010 (PubMed).

Alternatives for antigen "Glyceraldehyde-3-Phosphate Dehydrogenase, Spermatogenic (GAPDHS)", type "Antibodies"
Hosts (22), (6), (1)
Reactivities (26), (16), (16), (13), (13), (1), (1), (1)
Applications (20), (10), (8), (6), (3), (1), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (4), (2), (1)
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