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Glyceraldehyde-3-Phosphate Dehydrogenase, Spermatogenic (GAPDHS) (AA 1-409) antibody

Details for Product No. ABIN395555, Supplier: Log in to see
Antigen
  • GAPDS
  • GAPDHS
  • GAPD2
  • GAPDH-2
  • HSD-35
  • Gapd-s
  • Gapds
  • gapdh-2
  • cb350
  • fb71f08
  • fk58c09
  • g3pdh
  • gapdh
  • gapds
  • wu:fb71f08
  • wu:fk58c09
  • zgc:76908
  • glyceraldehyde-3-phosphate dehydrogenase, spermatogenic
  • GAPDHS
  • LOC100352213
  • Gapdhs
  • gapdhs
Epitope
AA 1-409
9
8
5
4
3
2
1
Reactivity
Human
55
27
25
5
4
1
1
1
1
1
Host
Mouse
35
18
2
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), ELISA, Western Blotting (WB)
41
16
13
12
8
4
3
3
3
1
Options
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Immunogen GAPDS (AAH36373, 1 a.a. ~ 409 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 2E3-2E10
Isotype IgG1 kappa
Specificity GAPDS (AAH36373, 1 a.a. ~ 409 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name GAPDS (GAPDHS Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 44501 DA
Gene ID 12406
Research Area Metabolism, Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000 Immunohistochemistry ~~ 1.5ug/ml
Comment

Background: This gene encodes a protein belonging to the glyceraldehyde-3-phosphate dehydrogenase family of enzymes that play an important role in carbohydrate metabolism. Like its somatic cell counterpart, this sperm-specific enzyme functions in a nicotinamide adenine dinucleotide-dependent manner to remove hydrogen and add phosphate to glyceraldehyde 3-phosphate to form 1,3-diphosphoglycerate. During spermiogenesis, this enzyme may play an important role in regulating the switch between different energy-producing pathways, and it is required for sperm motility and male fertility.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Glyceraldehyde-3-Phosphate Dehydrogenase, Spermatogenic (GAPDHS) (AA 1-409) antibody (ABIN395555) Immunoperoxidase of monoclonal antibody to GAPDHS on formalin-fixed paraffin-embedded...
Immunohistochemistry (IHC) image for anti-Glyceraldehyde-3-Phosphate Dehydrogenase, Spermatogenic (GAPDHS) (AA 1-409) antibody (ABIN395555) anti-Glyceraldehyde-3-Phosphate Dehydrogenase, Spermatogenic (GAPDHS) (AA 1-409) antibody (Image 2)
Background publications Corneveaux, Myers, Allen, Pruzin, Ramirez, Engel, Nalls, Chen, Lee, Chewning, Villa, Meechoovet, Gerber, Frost, Benson, OReilly, Chibnik, Shulman, Singleton, Craig, Van Keuren-Jensen, Dunckley, Bennett, De Jager, Heward, Hardy, Reiman, Huentelman: "Association of CR1, CLU and PICALM with Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals." in: Human molecular genetics, Vol. 19, Issue 16, pp. 3295-301, 2010 (PubMed).

Shchutskaya, Elkina, Kuravsky, Bragina, Schmalhausen: "Investigation of glyceraldehyde-3-phosphate dehydrogenase from human sperms." in: Biochemistry. Biokhimii?a, Vol. 73, Issue 2, pp. 185-91, 2008 (PubMed).

Ewing, Chu, Elisma, Li, Taylor, Climie, McBroom-Cerajewski, Robinson, OConnor, Li, Taylor, Dharsee, Ho, Heilbut, Moore, Zhang, Ornatsky, Bukhman, Ethier, Sheng, Vasilescu, Abu-Farha, Lambert, Duewel et al.: "Large-scale mapping of human protein-protein interactions by mass spectrometry. ..." in: Molecular systems biology, Vol. 3, pp. 89, 2007 (PubMed).

Bertram, McQueen, Mullin, Blacker, Tanzi: "Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database." in: Nature genetics, Vol. 39, Issue 1, pp. 17-23, 2006 (PubMed).

Yatsenko, Roy, Chen, Ma, Murthy, Yan, Lamb, Matzuk: "Non-invasive genetic diagnosis of male infertility using spermatozoal RNA: KLHL10 mutations in oligozoospermic patients impair homodimerization." in: Human molecular genetics, Vol. 15, Issue 23, pp. 3411-9, 2006 (PubMed).