Yes-Associated Protein 1 (YAP1) (AA 53-162) antibody

Details for Product No. ABIN395579
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Antigen
Synonyms YAP1, YAP, YAP2, YAP65, YKI, AI325207, Yap, Yap65, Yki, Yorkie, cb194, sb:cb194, si:ch211-181p1.5, si:dkey-3b8.3, wu:fc18c04, zgc:158380, xyap, yap, yap2, yap65, yki, HCCA1, HCCA2, YY1AP
Epitope
AA 53-162
(31), (15), (12), (11), (7), (6), (5), (5), (4), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(148), (74), (72), (37), (26), (24), (24), (3), (2), (1), (1), (1), (1)
Host
Mouse
(124), (24), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(6), (5), (5), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (1), (1), (1)
Application
Immunofluorescence (IF), Western Blotting (WB)
(113), (64), (40), (34), (30), (24), (14), (10), (9), (6), (2), (1)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN395579
450.00 $
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Immunogen YAP1 (NP_006097, 53 a.a. ~ 162 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 2F12
Isotype IgG2a kappa
Specificity YAP1 (NP_006097, 53 a.a. ~ 162 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name YAP1
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 48755 DA
Gene ID 12406
NCBI Accession NP_006097
Research Area Cell Signaling, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: This gene encodes the human ortholog of chicken YAP protein which binds to the SH3 domain of the Yes proto-oncogene product. This protein contains a WW domain that is found in various structural, regulatory and signaling molecules in yeast, nematode, and mammals, and may be involved in protein-protein interaction.

Restrictions For Research Use only
Concentration 0.5 mg/ml
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Yes-Associated Protein 1 (YAP1) (AA 53-162) antibody Immunofluorescence of monoclonal antibody to YAP1 on HeLa cell (antibody concentration 30 µg/mL). YAP1 monoclonal antibody (M01), clone 2F12 Western Blot analysis of YAP1 expression in Hela NE.
anti-Yes-Associated Protein 1 (YAP1) (AA 53-162) antibody (2) anti-Yes-Associated Protein 1 (YAP1) (AA 53-162) antibody (Image 2)
Background publications Zhao, Li, Tumaneng et al.: "A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF(beta-TRCP)." in: Genes & development, Vol. 24, Issue 1, pp. 72-85, 2010 (PubMed).

Watt, Judson, Medlow et al.: "Yap is a novel regulator of C2C12 myogenesis." in: Biochemical and biophysical research communications, Vol. 393, Issue 4, pp. 619-24, 2010 (PubMed).

Wang, Dong, Zhang et al.: "Overexpression of yes-associated protein contributes to progression and poor prognosis of non-small-cell lung cancer." in: Cancer science, Vol. 101, Issue 5, pp. 1279-85, 2010 (PubMed).

Liu, Poon, Luk: "MicroRNA-375 targets Hippo-signaling effector YAP in liver cancer and inhibits tumor properties." in: Biochemical and biophysical research communications, Vol. 394, Issue 3, pp. 623-7, 2010 (PubMed).

Rose, Behm, Drgon et al.: "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score." in: Molecular medicine (Cambridge, Mass.), Vol. 16, Issue 7-8, pp. 247-53, 2010 (PubMed).

Validation Images
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