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GTPase Activating Protein (SH3 Domain) Binding Protein 1 (G3BP1) (AA 214-303) antibody

Details for Product No. ABIN395586, Supplier: Log in to see
Antigen
  • fj17h05
  • zgc:56034
  • wu:fj17h05
  • g3bp
  • MGC53271
  • G3BP1
  • G3BP
  • HDH-VIII
  • G3bp
  • RGD1310666
  • AI849976
  • B430204O07
  • C87777
  • mKIAA4115
  • AA409541
  • E430034L04Rik
  • mKIAA0660
Epitope
AA 214-303
45
20
15
12
7
7
5
4
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
136
29
15
12
3
1
1
Host
Mouse
121
14
1
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
Application
Immunofluorescence (IF), Western Blotting (WB)
115
71
41
33
18
11
11
4
3
2
1
1
Supplier
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Immunogen G3BP (AAH06997, 214 a.a. ~ 303 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 2F3
Isotype IgG1 kappa
Specificity G3BP (AAH06997, 214 a.a. ~ 303 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name G3BP (G3BP1 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 52164 DA
Gene ID 12406
Research Area Cell Signaling, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: This gene encodes one of the DNA-unwinding enzymes which prefers partially unwound 3'-tailed substrates and can also unwind partial RNA/DNA and RNA/RNA duplexes in an ATP-dependent fashion. This enzyme is a member of the heterogeneous nuclear RNA-binding proteins and is also an element of the Ras signal transduction pathway. It binds specifically to the Ras-GTPase-activating protein by associating with its SH3 domain. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-GTPase Activating Protein (SH3 Domain) Binding Protein 1 (G3BP1) (AA 214-303) antibody (ABIN395586) Immunofluorescence of monoclonal antibody to G3BP on HeLa cell (antibody concentratio...
Immunohistochemistry (IHC) image for anti-GTPase Activating Protein (SH3 Domain) Binding Protein 1 (G3BP1) (AA 214-303) antibody (ABIN395586) anti-GTPase Activating Protein (SH3 Domain) Binding Protein 1 (G3BP1) (AA 214-303) antibody (Image 2)
Background publications Gao, Ge, Shao et al.: "Tudor-SN interacts with and co-localizes with G3BP in stress granules under stress conditions." in: FEBS letters, Vol. 584, Issue 16, pp. 3525-32, 2010 (PubMed).

Shim, Su, Chae et al.: "Epigallocatechin gallate suppresses lung cancer cell growth through Ras-GTPase-activating protein SH3 domain-binding protein 1." in: Cancer prevention research (Philadelphia, Pa.), Vol. 3, Issue 5, pp. 670-9, 2010 (PubMed).

Hinton, Myers, Roggero et al.: "The pseudophosphatase MK-STYX interacts with G3BP and decreases stress granule formation." in: The Biochemical journal, Vol. 427, Issue 3, pp. 349-57, 2010 (PubMed).

Sowa, Bennett, Gygi et al.: "Defining the human deubiquitinating enzyme interaction landscape." in: Cell, Vol. 138, Issue 2, pp. 389-403, 2009 (PubMed).

Barbe, Lundberg, Oksvold et al.: "Toward a confocal subcellular atlas of the human proteome." in: Molecular & cellular proteomics : MCP, Vol. 7, Issue 3, pp. 499-508, 2008 (PubMed).