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Details for Product No. ABIN395586

GTPase Activating Protein (SH3 Domain) Binding Protein 1 (G3BP1) antibody

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Antigen
Synonyms G3BP, HDH-VIII, G3bp, RGD1310666, AI849976, B430204O07, C87777, mKIAA4115, fj17h05, zgc:56034, wu:fj17h05, g3bp, MGC53271, G3BP1
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN395586
Quantity 0.1 mg
Price
450.00 $   Plus shipping costs $45.00
Shipping to
Availability Will be delivered in 2 to 3 Business Days
Immunogen G3BP (AAH06997, 214 a.a. ~ 303 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 2F3
Isotype IgG1 kappa
Specificity G3BP (AAH06997, 214 a.a. ~ 303 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name G3BP
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 52164 DA
Gene ID 12406
Research Area Cell Signaling, Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000 Immunohistochemistry ~~ 1.5ug/ml Immunofluorescence
Comment

Background: This gene encodes one of the DNA-unwinding enzymes which prefers partially unwound 3'-tailed substrates and can also unwind partial RNA/DNA and RNA/RNA duplexes in an ATP-dependent fashion. This enzyme is a member of the heterogeneous nuclear RNA-binding proteins and is also an element of the Ras signal transduction pathway. It binds specifically to the Ras-GTPase-activating protein by associating with its SH3 domain. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Barbe, Lundberg, Oksvold et al.: "Toward a confocal subcellular atlas of the human proteome." in: Molecular & cellular proteomics : MCP, Vol. 7, Issue 3, pp. 499-508, 2008 (PubMed).

Sowa, Bennett, Gygi et al.: "Defining the human deubiquitinating enzyme interaction landscape." in: Cell, Vol. 138, Issue 2, pp. 389-403, 2009 (PubMed).

Hinton, Myers, Roggero et al.: "The pseudophosphatase MK-STYX interacts with G3BP and decreases stress granule formation." in: The Biochemical journal, Vol. 427, Issue 3, pp. 349-57, 2010 (PubMed).

Shim, Su, Chae et al.: "Epigallocatechin gallate suppresses lung cancer cell growth through Ras-GTPase-activating protein SH3 domain-binding protein 1." in: Cancer prevention research (Philadelphia, Pa.), Vol. 3, Issue 5, pp. 670-9, 2010 (PubMed).

Gao, Ge, Shao et al.: "Tudor-SN interacts with and co-localizes with G3BP in stress granules under stress conditions." in: FEBS letters, Vol. 584, Issue 16, pp. 3525-32, 2010 (PubMed).

Alternatives for antigen "GTPase Activating Protein (SH3 Domain) Binding Protein 1 (G3BP1)", type "Antibodies"
Hosts (78), (5), (1)
Reactivities (82), (31), (25), (24), (17), (14), (1)
Applications (64), (30), (24), (22), (20), (17), (4), (3), (1), (1), (1)
Conjugates (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Epitopes (33), (5), (5), (3), (2), (2), (2), (2), (1), (1), (1), (1)
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