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GTPase Activating Protein (SH3 Domain) Binding Protein 1 (G3BP1) antibody

Details for Product No. ABIN395586
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Antigen
Synonyms G3BP, HDH-VIII, G3bp, RGD1310666, AI849976, B430204O07, C87777, mKIAA4115, fj17h05, zgc:56034, wu:fj17h05, g3bp, MGC53271, G3BP1
Reactivity
Human
(103), (35), (25), (24), (18), (13)
Host
Mouse
(94), (11)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(4), (4), (4), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Application
Immunofluorescence (IF), Western Blotting (WB)
(85), (47), (35), (24), (20), (19), (9), (7), (2), (2), (1)
Pubmed 5 references available
Quantity 0.1 mg
Options
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Catalog No. ABIN395586
450.00 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen G3BP (AAH06997, 214 a.a. ~ 303 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 2F3
Isotype IgG1 kappa
Specificity G3BP (AAH06997, 214 a.a. ~ 303 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name G3BP
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 52164 DA
Gene ID 12406
Research Area Cell Signaling, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: This gene encodes one of the DNA-unwinding enzymes which prefers partially unwound 3'-tailed substrates and can also unwind partial RNA/DNA and RNA/RNA duplexes in an ATP-dependent fashion. This enzyme is a member of the heterogeneous nuclear RNA-binding proteins and is also an element of the Ras signal transduction pathway. It binds specifically to the Ras-GTPase-activating protein by associating with its SH3 domain. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-GTPase Activating Protein (SH3 Domain) Binding Protein 1 (G3BP1) antibody Immunofluorescence of monoclonal antibody to G3BP on HeLa cell (antibody concentration 10 µg/mL). Western blot analysis of G3BP over-expressed 293 cell line, cotransfected with G3BP Validated Chimera RNAi used as specificity and loading control.
anti-GTPase Activating Protein (SH3 Domain) Binding Protein 1 (G3BP1) antibody (2) anti-GTPase Activating Protein (SH3 Domain) Binding Protein 1 (G3BP1) antibody (Image 2)
Background publications Barbe, Lundberg, Oksvold et al.: "Toward a confocal subcellular atlas of the human proteome." in: Molecular & cellular proteomics : MCP, Vol. 7, Issue 3, pp. 499-508, 2008 (PubMed).

Sowa, Bennett, Gygi et al.: "Defining the human deubiquitinating enzyme interaction landscape." in: Cell, Vol. 138, Issue 2, pp. 389-403, 2009 (PubMed).

Hinton, Myers, Roggero et al.: "The pseudophosphatase MK-STYX interacts with G3BP and decreases stress granule formation." in: The Biochemical journal, Vol. 427, Issue 3, pp. 349-57, 2010 (PubMed).

Shim, Su, Chae et al.: "Epigallocatechin gallate suppresses lung cancer cell growth through Ras-GTPase-activating protein SH3 domain-binding protein 1." in: Cancer prevention research (Philadelphia, Pa.), Vol. 3, Issue 5, pp. 670-9, 2010 (PubMed).

Gao, Ge, Shao et al.: "Tudor-SN interacts with and co-localizes with G3BP in stress granules under stress conditions." in: FEBS letters, Vol. 584, Issue 16, pp. 3525-32, 2010 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN395586
450.00 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
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