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Details for Product No. ABIN395591

rho Guanine Nucleotide Exchange Factor (GEF) 11 (ARHGEF11) antibody

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Synonyms Gtrap48, GTRAP48, PDZ-RHOGEF, B930073M02, E130307F09, PDZ-RhoGEF, Prg, RhoGEF, mKIAA0380, ARHGEF11
»Alternatives Human
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
»Alternatives Un-conjugated
»Alternatives ELISA, Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN395591
Quantity 0.1 mg
450.00 $   Plus shipping costs $45.00
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Immunogen ARHGEF11 (AAH57394, 651 a.a. ~ 750 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 2F4
Isotype IgG1 kappa
Specificity ARHGEF11 (AAH57394, 651 a.a. ~ 750 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name ARHGEF11
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 167704 DA
Gene ID 12406
Research Area Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000

Background: Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. A similar protein in rat interacts with glutamate transporter EAAT4 and modulates its glutamate transport activity. Expression of the rat protein induces the reorganization of the actin cytoskeleton and its overexpression induces the formation of membrane ruffling and filopodia. Two alternative transcripts encoding different isoforms have been described.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Zheng, Cierpicki, Momotani et al.: "On the mechanism of autoinhibition of the RhoA-specific nucleotide exchange factor PDZRhoGEF." in: BMC structural biology, Vol. 9, pp. 36, 2009 (PubMed).

Banerjee, Fischer, Wedegaertner: "The amino acid motif L/IIxxFE defines a novel actin-binding sequence in PDZ-RhoGEF." in: Biochemistry, Vol. 48, Issue 33, pp. 8032-43, 2009 (PubMed).

Ying, Giachini, Tostes et al.: "PYK2/PDZ-RhoGEF links Ca2+ signaling to RhoA." in: Arteriosclerosis, thrombosis, and vascular biology, Vol. 29, Issue 10, pp. 1657-63, 2009 (PubMed).

Rose, Behm, Drgon et al.: "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score." in: Molecular medicine (Cambridge, Mass.), Vol. 16, Issue 7-8, pp. 247-53, 2010 (PubMed).

Akiyama, Narita, Nakaoka et al.: "Genome-wide association study to identify genetic variants present in Japanese patients harboring intracranial aneurysms." in: Journal of human genetics, Vol. 55, Issue 10, pp. 656-61, 2010 (PubMed).

Alternatives for antigen "rho Guanine Nucleotide Exchange Factor (GEF) 11 (ARHGEF11)", type "Antibodies"
Hosts (39), (5)
Reactivities (44), (32), (32), (24), (15), (14), (3), (3), (2), (2), (1)
Applications (25), (20), (15), (14), (2)
Conjugates (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Epitopes (4), (4), (2), (2), (1), (1), (1)