S100 Calcium Binding Protein A11 (S100A11) antibody

Antigen: S100 Calcium Binding Protein A11 (S100A11)

Synonyms: MLN70, S100C

Clonality: Monoclonal (2F4)

Host: Mouse

Reactivity: Human

Conjugate: Un-conjugated

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)

Certificates: ISO 9001:2008

Catalog no.: ABIN395596

Additional Information

Alternative name: S100A11

Gene ID: 6282

Immunogen: S100A11 (AAH14354, 1 a.a. ~ 106 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K

Isotype: IgG2a kappa

Clone: 2F4

Description: Other names: MLN70, S100CS100 calcium binding protein A11 (calgizzarin)

Characteristics: Purified Mouse Monoclonal Antibody (Mab)

Specificity: S100A11 (AAH14354, 1 a.a. ~ 106 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Molecular Weight: 11740 DA

Comments:

Background: The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in motility, invasion, and tubulin polymerization. Chromosomal rearrangements and altered expression of this gene have been implicated in tumor metastasis.

Application Details

Application Notes: ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000 Immunohistochemistry ~~ 1.5ug/ml

Concentration: 0.5 mg/ml

Purification: Purified

Buffer: Clear, colorless solution in phosphate buffered saline, pH 7.2 .

Storage: Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles

Research Area: Cancer, Cell Structure

Restrictions: For Research Use only

Images

Immunoperoxidase of monoclonal antibody to S100A11 ( Cat # AT3752a ) on formalin-fixed paraffin-embedded human placenta. [antibody concentration 3 ug/ml] Detection limit for recombinant GST tagged S100A11 is approximately 0.03ng/ml as a capture antibody.

anti-S100 Calcium Binding Protein A11 (S100A11) antibody (Image 2)

Publications

Product: Bin, Howell, Kim et al.: "Inhibition of S100A11 gene expression impairs keratinocyte response against vaccinia virus through downregulation of the IL-10 receptor 2 chain." in: The Journal of allergy and clinical immunology, Vol. 124, Issue 2, pp. 270-7, 277.e1, 2009 (PubMed).

Medland, Nyholt, Painter et al.: "Common variants in the trichohyalin gene are associated with straight hair in Europeans." in: American journal of human genetics, Vol. 85, Issue 5, pp. 750-5, 2009 (PubMed).

Marlatt, Spratt, Shaw: "Codon optimization for enhanced Escherichia coli expression of human S100A11 and S100A1 proteins." in: Protein expression and purification, Vol. 73, Issue 1, pp. 58-64, 2010 (PubMed).

Liu, Wang, Li et al.: "Ca2+-binding protein S100A11: a novel diagnostic marker for breast carcinoma." in: Oncology reports, Vol. 23, Issue 5, pp. 1301-8, 2010 (PubMed).

Rose, Behm, Drgon et al.: "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score." in: Molecular medicine (Cambridge, Mass.), Vol. 16, Issue 7-8, pp. 247-53, 2010 (PubMed).