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D Amino Acid Oxidase antibody (D-Amino-Acid Oxidase) (AA 119-219)

Details for Product anti-DAO Antibody No. ABIN395600, Supplier: Log in to see
Antigen
  • 1600012D06Rik
  • Abp
  • Abp1
  • AI987963
  • DAAO
  • daao
  • DAMOX
  • damox
  • DAO
  • dao
  • Dao-1
  • Dao1
  • DKFZp469N2232
  • MGC114783
  • oxda
  • OXDA
  • SC5F2A.23c
  • wu:fb55b11
  • zgc:76928
  • zgc:77858
  • zgc:113922
Epitope
AA 119-219
30
14
11
11
10
3
2
2
1
Reactivity
Human
60
27
18
13
2
2
1
Host
Mouse
42
38
14
4
Clonality (Clone)
Monoclonal ()
Conjugate
This D Amino Acid Oxidase antibody is un-conjugated
11
7
5
5
5
5
Application
ELISA
77
63
12
11
10
5
3
2
2
2
2
1
1
Supplier
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Supplier Product No.
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Immunogen DAO (NP_001908, 119 a.a. ~ 219 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 2F5
Isotype IgG2a kappa
Specificity DAO (NP_001908, 119 a.a. ~ 219 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name DAO (DAO Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 39474 DA
Gene ID 12406
NCBI Accession NP_001908
Research Area Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml
Comment

Background: This gene encodes the peroxisomal enzyme D-amino acid oxidase. The enzyme is a flavoprotein which uses flavin adenine dinucleotide (FAD) as its prosthetic group. Its substrates include a wide variety of D-amino acids, but it is inactive on the naturally occurring L-amino acids. Its biological function is not known, it may act as a detoxifying agent which removes D-amino acids that accumulate during aging. In mice, it degrades D-serine, a co-agonist of the NMDA receptor. This gene may play a role in the pathophysiology of schizophrenia.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
ELISA image for anti-D Amino Acid Oxidase antibody (D-Amino-Acid Oxidase) (AA 119-219) (ABIN395600) Detection limit for recombinant GST tagged DAO is approximately 0.03 ng/mL as a captu...
Background publications Ruaño, Thompson, Kane, Pullinger, Windemuth, Seip, Kocherla, Holford, Wu: "Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol?" in: Pharmacogenomics, Vol. 11, Issue 7, pp. 959-71, 2010 (PubMed).

Kim, Kim, Joo, Lim, Kim, Song: "Sex-different association of DAO with schizophrenia in Koreans." in: Psychiatry research, Vol. 179, Issue 2, pp. 121-5, 2010 (PubMed).

Mitchell, Paul, Chen, Morris, Payling, Falchi, Habgood, Panoutsou, Winkler, Tisato, Hajitou, Smith, Vance, Shaw, Mazarakis, de Belleroche: "Familial amyotrophic lateral sclerosis is associated with a mutation in D-amino acid oxidase." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 16, pp. 7556-61, 2010 (PubMed).

Ohnuma, Shibata, Baba, Ohi, Yasuda, Nakamura, Okochi, Naitoh, Hashimoto, Iwata, Ozaki, Takeda, Arai: "No association between DAO and schizophrenia in a Japanese patient population: a multicenter replication study." in: Schizophrenia research, Vol. 118, Issue 1-3, pp. 300-2, 2010 (PubMed).

Habl, Zink, Petroianu, Bauer, Schneider-Axmann, von Wilmsdorff, Falkai, Henn, Schmitt: "Increased D-amino acid oxidase expression in the bilateral hippocampal CA4 of schizophrenic patients: a post-mortem study." in: Journal of neural transmission (Vienna, Austria : 1996), Vol. 116, Issue 12, pp. 1657-65, 2010 (PubMed).