D-Amino-Acid Oxidase (DAO) (AA 119-219) antibody

Details for Product No. ABIN395600
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Antigen
Synonyms daao, oxda, damox, dao, DAO, DKFZp469N2232, zgc:77858, zgc:76928, SC5F2A.23c, wu:fb55b11, zgc:113922, MGC114783, Abp, Abp1, 1600012D06Rik, DAAO, DAMOX, AI987963, Dao-1, Dao1, OXDA
Epitope
AA 119-219
(6), (4), (3), (2), (2), (2), (2)
Reactivity
Human
(25), (21), (4), (3), (1), (1)
Host
Mouse
(21), (13), (10), (3)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(7), (3), (1), (1), (1), (1)
Application
ELISA
(36), (36), (12), (6), (6), (4), (2), (2), (2), (2)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN395600
450.00 $
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Immunogen DAO (NP_001908, 119 a.a. ~ 219 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 2F5
Isotype IgG2a kappa
Specificity DAO (NP_001908, 119 a.a. ~ 219 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name DAO
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 39474 DA
Gene ID 12406
NCBI Accession NP_001908
Research Area Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml
Comment

Background: This gene encodes the peroxisomal enzyme D-amino acid oxidase. The enzyme is a flavoprotein which uses flavin adenine dinucleotide (FAD) as its prosthetic group. Its substrates include a wide variety of D-amino acids, but it is inactive on the naturally occurring L-amino acids. Its biological function is not known, it may act as a detoxifying agent which removes D-amino acids that accumulate during aging. In mice, it degrades D-serine, a co-agonist of the NMDA receptor. This gene may play a role in the pathophysiology of schizophrenia.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-D-Amino-Acid Oxidase (DAO) (AA 119-219) antibody Detection limit for recombinant GST tagged DAO is approximately 0.03 ng/mL as a capture antibody.
Background publications Habl, Zink, Petroianu et al.: "Increased D-amino acid oxidase expression in the bilateral hippocampal CA4 of schizophrenic patients: a post-mortem study." in: Journal of neural transmission (Vienna, Austria : 1996), Vol. 116, Issue 12, pp. 1657-65, 2010 (PubMed).

Ohnuma, Shibata, Baba et al.: "No association between DAO and schizophrenia in a Japanese patient population: a multicenter replication study." in: Schizophrenia research, Vol. 118, Issue 1-3, pp. 300-2, 2010 (PubMed).

Mitchell, Paul, Chen et al.: "Familial amyotrophic lateral sclerosis is associated with a mutation in D-amino acid oxidase." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 16, pp. 7556-61, 2010 (PubMed).

Kim, Kim, Joo et al.: "Sex-different association of DAO with schizophrenia in Koreans." in: Psychiatry research, Vol. 179, Issue 2, pp. 121-5, 2010 (PubMed).

Ruaño, Thompson, Kane et al.: "Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol?" in: Pharmacogenomics, Vol. 11, Issue 7, pp. 959-71, 2010 (PubMed).

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