D-Amino-Acid Oxidase (DAO) antibody

Details for Product No. ABIN395600
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Synonyms DAAO, DAMOX, OXDA, DAO, 1600012D06Rik, Abp1, Abp, Dao, daao, oxda, damox, dao, DKFZp469N2232, zgc:77858, zgc:76928, SC5F2A.23c, wu:fb55b11, zgc:113922, MGC114783
(22), (16), (5), (4), (1), (1)
(18), (9), (9), (4)
Clonality (Clone)
Monoclonal ()
(6), (1)
(35), (29), (9), (6), (4), (4), (2), (2), (2), (2), (2), (2)
Pubmed 5 references available
Catalog no. ABIN395600
Quantity 0.1 mg
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Immunogen DAO (NP_001908, 119 a.a. ~ 219 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 2F5
Isotype IgG2a kappa
Specificity DAO (NP_001908, 119 a.a. ~ 219 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name DAO
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 39474 DA
Gene ID 12406
UniProt NP_001908
Research Area Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml

Background: This gene encodes the peroxisomal enzyme D-amino acid oxidase. The enzyme is a flavoprotein which uses flavin adenine dinucleotide (FAD) as its prosthetic group. Its substrates include a wide variety of D-amino acids, but it is inactive on the naturally occurring L-amino acids. Its biological function is not known, it may act as a detoxifying agent which removes D-amino acids that accumulate during aging. In mice, it degrades D-serine, a co-agonist of the NMDA receptor. This gene may play a role in the pathophysiology of schizophrenia.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-D-Amino-Acid Oxidase (DAO) antibody Detection limit for recombinant GST tagged DAO is approximately 0.03 ng/mL as a capture antibody.
Background publications Habl, Zink, Petroianu et al.: "Increased D-amino acid oxidase expression in the bilateral hippocampal CA4 of schizophrenic patients: a post-mortem study." in: Journal of neural transmission (Vienna, Austria : 1996), Vol. 116, Issue 12, pp. 1657-65, 2010 (PubMed).

Ohnuma, Shibata, Baba et al.: "No association between DAO and schizophrenia in a Japanese patient population: a multicenter replication study." in: Schizophrenia research, Vol. 118, Issue 1-3, pp. 300-2, 2010 (PubMed).

Mitchell, Paul, Chen et al.: "Familial amyotrophic lateral sclerosis is associated with a mutation in D-amino acid oxidase." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 16, pp. 7556-61, 2010 (PubMed).

Kim, Kim, Joo et al.: "Sex-different association of DAO with schizophrenia in Koreans." in: Psychiatry research, Vol. 179, Issue 2, pp. 121-5, 2010 (PubMed).

Ruaño, Thompson, Kane et al.: "Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol?" in: Pharmacogenomics, Vol. 11, Issue 7, pp. 959-71, 2010 (PubMed).

Hosts (18), (9), (9), (4)
Reactivities (22), (16), (5), (4), (1), (1)
Applications (35), (29), (9), (6), (4), (4), (2), (2), (2), (2), (2), (2)
Conjugates (6), (1)
Epitopes (4), (2), (2), (2), (2), (1), (1)
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