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Intercellular Adhesion Molecule 3 (ICAM3) (AA 30-548) antibody

Details for Product No. ABIN395624, Supplier: Log in to see
Antigen
  • ICAM3
  • CD50
  • CDW50
  • ICAM-R
  • ICAM-3
  • Icam3
  • TLN
  • Tlcn
Epitope
AA 30-548
15
14
9
8
8
5
4
2
2
2
2
1
1
1
1
1
1
1
1
Reactivity
Human
229
3
2
2
2
Host
Mouse
169
58
1
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
26
18
15
5
3
3
1
Application
Western Blotting (WB)
124
94
73
49
46
31
27
8
7
7
5
5
4
2
1
1
1
Supplier
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Immunogen ICAM3 (AAH58903, 30 a.a. ~ 548 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 2F8
Isotype IgG2b kappa
Specificity ICAM3 (AAH58903, 30 a.a. ~ 548 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name ICAM3 (ICAM3 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 59541 DA
Gene ID 12406
Research Area Cell Structure
Pathways
Application Notes Western blot = 1:500-1000
Comment

Background: The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is constitutively and abundantly expressed by all leucocytes and may be the most important ligand for LFA-1 in the initiation of the immune response. It functions not only as an adhesion molecule, but also as a potent signalling molecule.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Intercellular Adhesion Molecule 3 (ICAM3) (AA 30-548) antibody (ABIN395624) ICAM3 monoclonal antibody (M01), clone 2F8 Western Blot analysis of ICAM3 expression ...
Immunohistochemistry (IHC) image for anti-Intercellular Adhesion Molecule 3 (ICAM3) (AA 30-548) antibody (ABIN395624) anti-Intercellular Adhesion Molecule 3 (ICAM3) (AA 30-548) antibody (Image 2)
Background publications Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Han, Lan, Park et al.: "Polymorphisms in innate immunity genes and risk of childhood leukemia." in: Human immunology, Vol. 71, Issue 7, pp. 727-30, 2010 (PubMed).

Rajaraman, Brenner, Neta et al.: "Risk of meningioma and common variation in genes related to innate immunity." in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 19, Issue 5, pp. 1356-61, 2010 (PubMed).

Mosbruger, Duggal, Goedert et al.: "Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus." in: The Journal of infectious diseases, Vol. 201, Issue 9, pp. 1371-80, 2010 (PubMed).

Reuss, Schreiber, Klein et al.: "No significant effect of orally administered chemokine receptor 1 antagonist on intercellular adhesion molecule-3 expression in relapsing--remitting multiple sclerosis patients." in: Multiple sclerosis (Houndmills, Basingstoke, England), Vol. 16, Issue 3, pp. 366-9, 2010 (PubMed).