Intercellular Adhesion Molecule 3 (ICAM3) antibody

Antigen: Intercellular Adhesion Molecule 3 (ICAM3)

Synonyms: CD50, CDW50, ICAM-R, TLN, Tlcn, Icam3, ICAM-3, MGC130520, ICAM3, FLJ12949

Clonality: Monoclonal (2F8)

Host: Mouse

Reactivity: Human

Conjugate: Un-conjugated

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)

Certificates: ISO 9001:2008

Catalog no.: ABIN395624

Additional Information

Alternative name: ICAM3

Gene ID: 3385

Immunogen: ICAM3 (AAH58903, 30 a.a. ~ 548 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K

Isotype: IgG2b kappa

Clone: 2F8

Description: Other names: CD50, CDW50, ICAMR intercellular adhesion molecule 3

Characteristics: Purified Mouse Monoclonal Antibody (Mab)

Specificity: ICAM3 (AAH58903, 30 a.a. ~ 548 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Molecular Weight: 59541 DA

Comments:

Background: The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is constitutively and abundantly expressed by all leucocytes and may be the most important ligand for LFA-1 in the initiation of the immune response. It functions not only as an adhesion molecule, but also as a potent signalling molecule.

Application Details

Application Notes: ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000 Immunohistochemistry ~~ 1.5ug/ml

Purification: Purified

Buffer: Clear, colorless solution in phosphate buffered saline, pH 7.2 .

Storage: Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles

Research Area: Cell Structure

Restrictions: For Research Use only

Images

ICAM3 monoclonal antibody (M01), clone 2F8 Western Blot analysis of ICAM3 expression in HL-60 ( Cat # L014V1 ). Immunoperoxidase of monoclonal antibody to ICAM3 ( Cat # AT2469a ) on formalin-fixed paraffin-embedded human stomach carcinoma tissue. [antibody concentration 3ug/ml]

anti-Intercellular Adhesion Molecule 3 (ICAM3) antibody (Image 2)

Publications

Product: Reuss, Schreiber, Klein et al.: "No significant effect of orally administered chemokine receptor 1 antagonist on intercellular adhesion molecule-3 expression in relapsing--remitting multiple sclerosis patients." in: Multiple sclerosis (Houndmills, Basingstoke, England), Vol. 16, Issue 3, pp. 366-9, 2010 (PubMed).

Mosbruger, Duggal, Goedert et al.: "Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus." in: The Journal of infectious diseases, Vol. 201, Issue 9, pp. 1371-80, 2010 (PubMed).

Rajaraman, Brenner, Neta et al.: "Risk of meningioma and common variation in genes related to innate immunity." in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 19, Issue 5, pp. 1356-61, 2010 (PubMed).

Han, Lan, Park et al.: "Polymorphisms in innate immunity genes and risk of childhood leukemia." in: Human immunology, Vol. 71, Issue 7, pp. 727-30, 2010 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).