DCP1 Decapping Enzyme Homolog A (S. Cerevisiae) (DCP1A) (AA 186-286) antibody

Details for Product No. ABIN395639
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Antigen
Synonyms DCP1A, 1110066A22Rik, 4930568L04Rik, AU019772, D14Ertd817e, Mitc1, SMIF, RGD1561298, mitc1, HSA275986, Nbla00360, SMAD4IP1, smad4ip1, smif
Epitope
AA 186-286
(10), (7), (5), (4), (3), (2), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(63), (31), (16), (14), (14), (12), (1), (1), (1)
Host
Mouse
(48), (10), (5)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(52), (30), (10), (6), (5), (4), (3), (2), (1)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN395639
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Immunogen DCP1A (NP_060873, 186 a.a. ~ 286 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 2G10
Isotype IgG1 kappa
Specificity DCP1A (NP_060873, 186 a.a. ~ 286 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name DCP1A
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 63278 DA
Gene ID 12406
NCBI Accession NP_060873
Research Area Cell Signaling, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: Decapping is a key step in general and regulated mRNA decay. The protein encoded by this gene is a decapping enzyme. This protein and another decapping enzyme form a decapping complex, which interacts with the nonsense-mediated decay factor hUpf1 and may be recruited to mRNAs containing premature termination codons. This protein also participates in the TGF-beta signaling pathway.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-DCP1 Decapping Enzyme Homolog A (S. Cerevisiae) (DCP1A) (AA 186-286) antibody DCP1A monoclonal antibody (M07), clone 2G10. Western Blot analysis of DCP1A expression in IMR-32.
Background publications Barbe, Lundberg, Oksvold et al.: "Toward a confocal subcellular atlas of the human proteome." in: Molecular & cellular proteomics : MCP, Vol. 7, Issue 3, pp. 499-508, 2008 (PubMed).

Penco, Buscema, Patrosso et al.: "New application of intelligent agents in sporadic amyotrophic lateral sclerosis identifies unexpected specific genetic background." in: BMC bioinformatics, Vol. 9, pp. 254, 2008 (PubMed).

Cho, Kim, Kim: "Human proline-rich nuclear receptor coregulatory protein 2 mediates an interaction between mRNA surveillance machinery and decapping complex." in: Molecular cell, Vol. 33, Issue 1, pp. 75-86, 2009 (PubMed).

Sowa, Bennett, Gygi et al.: "Defining the human deubiquitinating enzyme interaction landscape." in: Cell, Vol. 138, Issue 2, pp. 389-403, 2009 (PubMed).

Swetloff, Conne, Huarte et al.: "Dcp1-bodies in mouse oocytes." in: Molecular biology of the cell, Vol. 20, Issue 23, pp. 4951-61, 2009 (PubMed).

Validation Images
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