DCP1 Decapping Enzyme Homolog A (S. Cerevisiae) (DCP1A) antibody

Antigen: DCP1 Decapping Enzyme Homolog A (S. Cerevisiae) (DCP1A)

Synonyms: SMIF, FLJ21691, SMAD4IP1, HSA275986, Nbla00360, Mitc1, AU019772, D14Ertd817e, 1110066A22Rik, 4930568L04Rik, RGD1561298, DCP1A, MGC159576

Clonality: Monoclonal (2G10)

Host: Mouse

Reactivity: Human

Application: ELISA, Western Blotting (WB)

Certificates: ISO 9001:2008

Catalog no.: ABIN395639

Additional Information

Alternative name: DCP1A

Gene ID: 55802

UniProt: NP_060873

Immunogen: DCP1A (NP_060873, 186 a.a. ~ 286 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K

Isotype: IgG1 kappa

Clone: 2G10

Description: Other names: HSA275986, Nbla00360, SMAD4IP1, SMIF DCP1 decapping enzyme homolog A (S. cerevisiae)

Characteristics: Purified Mouse Monoclonal Antibody (Mab)

Specificity: DCP1A (NP_060873, 186 a.a. ~ 286 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Molecular Weight: 63278 DA

Comments:

Background: Decapping is a key step in general and regulated mRNA decay. The protein encoded by this gene is a decapping enzyme. This protein and another decapping enzyme form a decapping complex, which interacts with the nonsense-mediated decay factor hUpf1 and may be recruited to mRNAs containing premature termination codons. This protein also participates in the TGF-beta signaling pathway.

Application Details

Application Notes: ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000

Purification: Purified

Buffer: Clear, colorless solution in phosphate buffered saline, pH 7.2 .

Storage: Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles

Research Area: Cell Signaling, Cell Structure

Restrictions: For Research Use only

Images

DCP1A monoclonal antibody (M07), clone 2G10. Western Blot analysis of DCP1A expression in IMR-32 ( Cat # L008V1 ).

Publications

Product: Barbe, Lundberg, Oksvold et al.: "Toward a confocal subcellular atlas of the human proteome." in: Molecular & cellular proteomics : MCP, Vol. 7, Issue 3, pp. 499-508, 2008 (PubMed).

Penco, Buscema, Patrosso et al.: "New application of intelligent agents in sporadic amyotrophic lateral sclerosis identifies unexpected specific genetic background." in: BMC bioinformatics, Vol. 9, pp. 254, 2008 (PubMed).

Cho, Kim, Kim: "Human proline-rich nuclear receptor coregulatory protein 2 mediates an interaction between mRNA surveillance machinery and decapping complex." in: Molecular cell, Vol. 33, Issue 1, pp. 75-86, 2009 (PubMed).

Sowa, Bennett, Gygi et al.: "Defining the human deubiquitinating enzyme interaction landscape." in: Cell, Vol. 138, Issue 2, pp. 389-403, 2009 (PubMed).

Swetloff, Conne, Huarte et al.: "Dcp1-bodies in mouse oocytes." in: Molecular biology of the cell, Vol. 20, Issue 23, pp. 4951-61, 2009 (PubMed).