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DCP1 Decapping Enzyme Homolog A (S. Cerevisiae) (DCP1A) (AA 186-286) antibody

Details for Product No. ABIN395639, Supplier: Log in to see
Antigen
  • DCP1A
  • 1110066A22Rik
  • 4930568L04Rik
  • AU019772
  • D14Ertd817e
  • Mitc1
  • SMIF
  • RGD1561298
  • mitc1
  • HSA275986
  • Nbla00360
  • SMAD4IP1
  • smad4ip1
  • smif
Epitope
AA 186-286
20
15
14
5
5
4
2
2
2
1
1
1
1
1
1
1
1
Reactivity
Human
80
23
8
4
4
1
1
1
1
1
Host
Mouse
52
15
13
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
3
3
3
3
3
3
1
Application
Western Blotting (WB)
71
51
9
6
6
1
1
1
1
Supplier
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Immunogen DCP1A (NP_060873, 186 a.a. ~ 286 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 2G10
Isotype IgG1 kappa
Specificity DCP1A (NP_060873, 186 a.a. ~ 286 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name DCP1A (DCP1A Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 63278 DA
Gene ID 12406
NCBI Accession NP_060873
Research Area Cell Signaling, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: Decapping is a key step in general and regulated mRNA decay. The protein encoded by this gene is a decapping enzyme. This protein and another decapping enzyme form a decapping complex, which interacts with the nonsense-mediated decay factor hUpf1 and may be recruited to mRNAs containing premature termination codons. This protein also participates in the TGF-beta signaling pathway.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-DCP1 Decapping Enzyme Homolog A (S. Cerevisiae) (DCP1A) (AA 186-286) antibody (ABIN395639) DCP1A monoclonal antibody (M07), clone 2G10. Western Blot analysis of DCP1A expressio...
Background publications Swetloff, Conne, Huarte et al.: "Dcp1-bodies in mouse oocytes." in: Molecular biology of the cell, Vol. 20, Issue 23, pp. 4951-61, 2009 (PubMed).

Sowa, Bennett, Gygi et al.: "Defining the human deubiquitinating enzyme interaction landscape." in: Cell, Vol. 138, Issue 2, pp. 389-403, 2009 (PubMed).

Cho, Kim, Kim: "Human proline-rich nuclear receptor coregulatory protein 2 mediates an interaction between mRNA surveillance machinery and decapping complex." in: Molecular cell, Vol. 33, Issue 1, pp. 75-86, 2009 (PubMed).

Penco, Buscema, Patrosso et al.: "New application of intelligent agents in sporadic amyotrophic lateral sclerosis identifies unexpected specific genetic background." in: BMC bioinformatics, Vol. 9, pp. 254, 2008 (PubMed).

Barbe, Lundberg, Oksvold et al.: "Toward a confocal subcellular atlas of the human proteome." in: Molecular & cellular proteomics : MCP, Vol. 7, Issue 3, pp. 499-508, 2008 (PubMed).