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ALDH3A1 antibody (Aldehyde Dehydrogenase 3 Family, Member A1) (AA 1-454)

Details for Product anti-ALDH3A1 Antibody No. ABIN395668, Supplier: Log in to see
Antigen
  • ALDH3
  • ALDHIII
  • AHDC
  • Ahd-c
  • Aldh
  • Aldh3
  • Ahd-4
  • Ahd4
Epitope
AA 1-454
29
12
8
5
5
4
2
2
2
2
1
1
1
Reactivity
Human
86
38
22
3
3
1
Host
Mouse
70
14
10
2
Clonality (Clone)
Monoclonal ()
Conjugate
This ALDH3A1 antibody is un-conjugated
1
1
1
1
1
1
1
Application
ELISA
84
37
20
20
12
9
7
4
2
2
1
Supplier
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Immunogen ALDH3A1 (AAH04370, 1 a.a. ~ 454 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 2G4
Isotype IgG1 kappa
Specificity ALDH3A1 (AAH04370, 1 a.a. ~ 454 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name ALDH3A1 (ALDH3A1 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 50379 DA
Gene ID 12406
Research Area Metabolism, Cell Structure
Pathways
Application Notes ELISA ~~ 1ug/ml~3ng/ml
Comment

Background: Aldehyde dehydrogenases oxidize various aldehydes to the corresponding acids. They are involved in the detoxification of alcohol-derived acetaldehyde and in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. The enzyme encoded by this gene forms a cytoplasmic homodimer that preferentially oxidizes aromatic and medium-chain (6 carbons or more) saturated and unsaturated aldehyde substrates. It is thought to promote resistance to UV and 4-hydroxy-2-nonenal-induced oxidative damage in the cornea. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Restrictions For Research Use only
Concentration 0.5mg/ml
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
ELISA image for anti-ALDH3A1 antibody (Aldehyde Dehydrogenase 3 Family, Member A1) (AA 1-454) (ABIN395668) Detection limit for recombinant GST tagged ALDH3A1 is approximately 1 ng/mL as a capt...
Background publications Rose, Behm, Drgon et al.: "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score." in: Molecular medicine (Cambridge, Mass.), Vol. 16, Issue 7-8, pp. 247-53, 2010 (PubMed).

Davila, Froeling, Tan et al.: "New genetic associations detected in a host response study to hepatitis B vaccine." in: Genes and immunity, Vol. 11, Issue 3, pp. 232-8, 2010 (PubMed).

Searles Nielsen, McKean-Cowdin, Farin et al.: "Childhood brain tumors, residential insecticide exposure, and pesticide metabolism genes." in: Environmental health perspectives, Vol. 118, Issue 1, pp. 144-9, 2010 (PubMed).

Bogucka, Giebułtowicz, Zawada et al.: "The oxidation status of ALDH3A1 in human saliva and its correlation with antioxidant capacity measured by ORAC method." in: Acta poloniae pharmaceutica, Vol. 66, Issue 5, pp. 477-82, 2009 (PubMed).

Low, Kiyotani, Mushiroda et al.: "Association study of genetic polymorphism in ABCC4 with cyclophosphamide-induced adverse drug reactions in breast cancer patients." in: Journal of human genetics, Vol. 54, Issue 10, pp. 564-71, 2009 (PubMed).