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Details for Product No. ABIN395668

Aldehyde Dehydrogenase 3 Family, Member A1 (ALDH3A1) antibody

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Antigen
Synonyms ALDH3, ALDHIII, Ahd-4, Ahd4, Aldh, Aldh3, AHDC, Ahd-c
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Application
»Alternatives ELISA
Pubmed 5 references available
Catalog no. ABIN395668
Quantity 0.1 mg
Price
450.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen ALDH3A1 (AAH04370, 1 a.a. ~ 454 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 2G4
Isotype IgG1 kappa
Specificity ALDH3A1 (AAH04370, 1 a.a. ~ 454 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name ALDH3A1
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 50379 DA
Gene ID 12406
Research Area Metabolism, Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml
Comment

Background: Aldehyde dehydrogenases oxidize various aldehydes to the corresponding acids. They are involved in the detoxification of alcohol-derived acetaldehyde and in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. The enzyme encoded by this gene forms a cytoplasmic homodimer that preferentially oxidizes aromatic and medium-chain (6 carbons or more) saturated and unsaturated aldehyde substrates. It is thought to promote resistance to UV and 4-hydroxy-2-nonenal-induced oxidative damage in the cornea. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Restrictions For Research Use only
Concentration 0.5mg/ml
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Low, Kiyotani, Mushiroda et al.: "Association study of genetic polymorphism in ABCC4 with cyclophosphamide-induced adverse drug reactions in breast cancer patients." in: Journal of human genetics, Vol. 54, Issue 10, pp. 564-71, 2009 (PubMed).

Bogucka, Giebułtowicz, Zawada et al.: "The oxidation status of ALDH3A1 in human saliva and its correlation with antioxidant capacity measured by ORAC method." in: Acta poloniae pharmaceutica, Vol. 66, Issue 5, pp. 477-82, 2009 (PubMed).

Searles Nielsen, McKean-Cowdin, Farin et al.: "Childhood brain tumors, residential insecticide exposure, and pesticide metabolism genes." in: Environmental health perspectives, Vol. 118, Issue 1, pp. 144-9, 2010 (PubMed).

Davila, Froeling, Tan et al.: "New genetic associations detected in a host response study to hepatitis B vaccine." in: Genes and immunity, Vol. 11, Issue 3, pp. 232-8, 2010 (PubMed).

Rose, Behm, Drgon et al.: "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score." in: Molecular medicine (Cambridge, Mass.), Vol. 16, Issue 7-8, pp. 247-53, 2010 (PubMed).

Alternatives for antigen "Aldehyde Dehydrogenase 3 Family, Member A1 (ALDH3A1)", type "Antibodies"
Hosts (34), (7), (3), (1)
Reactivities (43), (17), (14), (1)
Applications (42), (20), (11), (10), (7), (6), (2), (2), (1)
Epitopes (15), (6), (5), (4), (2), (2), (2), (1), (1)
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