Aldehyde Dehydrogenase 3 Family, Member A1 (ALDH3A1) antibody

Antigen: Aldehyde Dehydrogenase 3 Family, Member A1 (ALDH3A1)

Synonyms: ALDH3A1, ALDH3, ALDHIII, MGC10406, ALDEHYDE DEHYDROGENASE 3, ALDEHYDE DEHYDROGENASE 3I1, ALDH3I1, F10M10.10, F10M10_10

Clonality: Monoclonal (2G4)

Host: Mouse

Reactivity: Human

Application: ELISA

Certificates: ISO 9001:2008

Catalog no.: ABIN395668

Additional Information

Alternative name: ALDH3A1

Gene ID: 218

Immunogen: ALDH3A1 (AAH04370, 1 a.a. ~ 454 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K

Isotype: IgG1 kappa

Clone: 2G4

Description: Other names: ALDH3, ALDHIII, MGC10406aldehyde dehydrogenase 3 family, memberA1

Characteristics: Purified Mouse Monoclonal Antibody (Mab)

Specificity: ALDH3A1 (AAH04370, 1 a.a. ~ 454 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Molecular Weight: 50379 DA

Comments:

Background: Aldehyde dehydrogenases oxidize various aldehydes to the corresponding acids. They are involved in the detoxification of alcohol-derived acetaldehyde and in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. The enzyme encoded by this gene forms a cytoplasmic homodimer that preferentially oxidizes aromatic and medium-chain (6 carbons or more) saturated and unsaturated aldehyde substrates. It is thought to promote resistance to UV and 4-hydroxy-2-nonenal-induced oxidative damage in the cornea. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Application Details

Application Notes: ELISA ~~ 1ug/ml~3ng/ml

Concentration: 0.5mg/ml

Purification: Purified

Buffer: Clear, colorless solution in phosphate buffered saline, pH 7.2 .

Storage: Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles

Research Area: Metabolism, Cell Structure

Restrictions: For Research Use only

Images

Detection limit for recombinant GST tagged ALDH3A1 is approximately 1ng/ml as a capture antibody.

Publications

Product: Low, Kiyotani, Mushiroda et al.: "Association study of genetic polymorphism in ABCC4 with cyclophosphamide-induced adverse drug reactions in breast cancer patients." in: Journal of human genetics, Vol. 54, Issue 10, pp. 564-71, 2009 (PubMed).

Bogucka, Giebułtowicz, Zawada et al.: "The oxidation status of ALDH3A1 in human saliva and its correlation with antioxidant capacity measured by ORAC method." in: Acta poloniae pharmaceutica, Vol. 66, Issue 5, pp. 477-82, 2009 (PubMed).

Searles Nielsen, McKean-Cowdin, Farin et al.: "Childhood brain tumors, residential insecticide exposure, and pesticide metabolism genes." in: Environmental health perspectives, Vol. 118, Issue 1, pp. 144-9, 2010 (PubMed).

Davila, Froeling, Tan et al.: "New genetic associations detected in a host response study to hepatitis B vaccine." in: Genes and immunity, Vol. 11, Issue 3, pp. 232-8, 2010 (PubMed).

Rose, Behm, Drgon et al.: "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score." in: Molecular medicine (Cambridge, Mass.), Vol. 16, Issue 7-8, pp. 247-53, 2010 (PubMed).