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Tryptophanyl-tRNA Synthetase, WARS (WARS) (AA 50-150) antibody

Details for Product No. ABIN395766, Supplier: Log in to see
Antigen
  • GAMMA-2
  • IFI53
  • IFP53
  • TrpRS
  • WRS
  • WARS
Epitope
AA 50-150
17
15
7
4
3
3
3
3
2
2
2
1
1
Reactivity
Human
52
9
9
Host
Mouse
51
7
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
2
2
2
2
2
2
Application
Immunofluorescence (IF), Western Blotting (WB)
46
30
8
8
6
4
3
3
Supplier
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Immunogen WARS (NP_004175, 50 a.a. ~ 150 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 3A12
Isotype IgG2a kappa
Specificity WARS (NP_004175, 50 a.a. ~ 150 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name WARS (WARS Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 53165 DA
Gene ID 12406
NCBI Accession NP_004175
Research Area Cell Structure
Pathways
Application Notes Western blot = 1:500-1000
Comment

Background: Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Two forms of tryptophanyl-tRNA synthetase exist, a cytoplasmic form, named WARS, and a mitochondrial form, named WARS2. Tryptophanyl-tRNA synthetase (WARS) catalyzes the aminoacylation of tRNA(trp) with tryptophan and is induced by interferon. Tryptophanyl-tRNA synthetase belongs to the class I tRNA synthetase family. Four transcript variants encoding two different isoforms have been found for this gene.

Restrictions For Research Use only
Concentration 1 mg/ml
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Tryptophanyl-tRNA Synthetase, WARS (WARS) (AA 50-150) antibody (ABIN395766) Immunofluorescence of monoclonal antibody to WARS on HeLa cell (antibody concentratio...
Immunohistochemistry (IHC) image for anti-Tryptophanyl-tRNA Synthetase, WARS (WARS) (AA 50-150) antibody (ABIN395766) anti-Tryptophanyl-tRNA Synthetase, WARS (WARS) (AA 50-150) antibody (Image 2)
Background publications Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Talmud, Drenos, Shah et al.: "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. ..." in: American journal of human genetics, Vol. 85, Issue 5, pp. 628-42, 2009 (PubMed).

Ghanipour, Jirström, Pontén et al.: "The prognostic significance of tryptophanyl-tRNA synthetase in colorectal cancer." in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 18, Issue 11, pp. 2949-56, 2009 (PubMed).

Bhattacharyya, Ghosh, Hansia et al.: "Allostery and conformational free energy changes in human tryptophanyl-tRNA synthetase from essential dynamics and structure networks." in: Proteins, Vol. 78, Issue 3, pp. 506-17, 2010 (PubMed).

Wang, Mao, Zhao et al.: "Increased TTS abrogates IDO-mediated CD4(+) T cells suppression in patients with Graves' disease." in: Endocrine, Vol. 36, Issue 1, pp. 119-25, 2009 (PubMed).