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Tryptophanyl-tRNA Synthetase, WARS (WARS) (AA 50-150) antibody

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Synonyms GAMMA-2, IFI53, IFP53, TrpRS, WRS, WARS
AA 50-150
(18), (15), (7), (4), (4), (4), (3), (3), (3), (2), (2), (1), (1), (1)
(56), (10), (10)
(57), (7)
Clonality (Clone)
Monoclonal ()
(2), (2), (2), (2), (2), (2)
Immunofluorescence (IF), Western Blotting (WB)
(52), (33), (10), (9), (9), (7), (7), (6), (2)
Pubmed 5 references available
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Quantity 0.1 mg
Shipping to United States ( )
Availability Will be delivered in 8 to 11 Business Days
Immunogen WARS (NP_004175, 50 a.a. ~ 150 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 3A12
Isotype IgG2a kappa
Specificity WARS (NP_004175, 50 a.a. ~ 150 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name WARS (WARS Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 53165 DA
Gene ID 12406
NCBI Accession NP_004175
Research Area Cell Structure
Application Notes Western blot = 1:500-1000

Background: Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Two forms of tryptophanyl-tRNA synthetase exist, a cytoplasmic form, named WARS, and a mitochondrial form, named WARS2. Tryptophanyl-tRNA synthetase (WARS) catalyzes the aminoacylation of tRNA(trp) with tryptophan and is induced by interferon. Tryptophanyl-tRNA synthetase belongs to the class I tRNA synthetase family. Four transcript variants encoding two different isoforms have been found for this gene.

Restrictions For Research Use only
Concentration 1 mg/ml
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Tryptophanyl-tRNA Synthetase, WARS (WARS) (AA 50-150) antibody (ABIN395766) Immunofluorescence of monoclonal antibody to WARS on HeLa cell (antibody concentratio...
Immunohistochemistry (IHC) image for anti-Tryptophanyl-tRNA Synthetase, WARS (WARS) (AA 50-150) antibody (ABIN395766) anti-Tryptophanyl-tRNA Synthetase, WARS (WARS) (AA 50-150) antibody (Image 2)
Background publications Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Talmud, Drenos, Shah et al.: "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. ..." in: American journal of human genetics, Vol. 85, Issue 5, pp. 628-42, 2009 (PubMed).

Ghanipour, Jirström, Pontén et al.: "The prognostic significance of tryptophanyl-tRNA synthetase in colorectal cancer." in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 18, Issue 11, pp. 2949-56, 2009 (PubMed).

Bhattacharyya, Ghosh, Hansia et al.: "Allostery and conformational free energy changes in human tryptophanyl-tRNA synthetase from essential dynamics and structure networks." in: Proteins, Vol. 78, Issue 3, pp. 506-17, 2010 (PubMed).

Wang, Mao, Zhao et al.: "Increased TTS abrogates IDO-mediated CD4(+) T cells suppression in patients with Graves' disease." in: Endocrine, Vol. 36, Issue 1, pp. 119-25, 2009 (PubMed).

Catalog No. ABIN395766
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