NADH Dehydrogenase (Ubiquinone) 1 alpha Subcomplex, 1, 7.5kDa (NDUFA1) antibody

Details for Product No. ABIN395873
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Synonyms 1810049F12Rik, MWFE, ZNF183, CI-MWFE, RGD1560955
(28), (13), (13), (12)
(24), (3)
Clonality (Clone)
Monoclonal ()
(3), (3), (3), (1), (1), (1), (1), (1), (1), (1), (1)
ELISA, Western Blotting (WB)
(14), (14), (10), (4), (1), (1), (1), (1)
Pubmed 5 references available
Catalog no. ABIN395873
Quantity 0.1 mg
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Immunogen NDUFA1 (AAH00266, 24 a.a. ~ 71 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 3B9-1A1
Isotype IgG1 kappa
Specificity NDUFA1 (AAH00266, 24 a.a. ~ 71 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name NDUFA1
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 8072 DA
Gene ID 12406
Research Area Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000

Background: The human NDUFA1 gene codes for an essential component of complex I of the respiratory chain, which transfers electrons from NADH to ubiquinone. It has been noted that the N-terminal hydrophobic domain has the potential to be folded into an alpha-helix spanning the inner mitochondrial membrane with a C-terminal hydrophilic domain interacting with globular subunits of complex I. The highly conserved two-domain structure suggests that this feature is critical for the protein function and might act as an anchor for the NADH:ubiquinone oxidoreductase complex at the inner mitochondrial membrane. However, the NDUFA1 peptide is one of about 31 components of the hydrophobic protein (HP) fraction of complex I which is involved in proton translocation. Thus the NDUFA1 peptide may also participate in that function.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Vogel, Dieteren, van den Heuvel et al.: "Identification of mitochondrial complex I assembly intermediates by tracing tagged NDUFS3 demonstrates the entry point of mitochondrial subunits." in: The Journal of biological chemistry, Vol. 282, Issue 10, pp. 7582-90, 2007 (PubMed).

Fernandez-Moreira, Ugalde, Smeets et al.: "X-linked NDUFA1 gene mutations associated with mitochondrial encephalomyopathy." in: Annals of neurology, Vol. 61, Issue 1, pp. 73-83, 2007 (PubMed).

Potluri, Davila, Ruiz-Pesini et al.: "A novel NDUFA1 mutation leads to a progressive mitochondrial complex I-specific neurodegenerative disease." in: Molecular genetics and metabolism, Vol. 96, Issue 4, pp. 189-95, 2009 (PubMed).

Saito, Kawamoto, Kamatani: "Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects." in: Journal of human genetics, Vol. 54, Issue 6, pp. 317-23, 2009 (PubMed).

Morán, Rivera, Sánchez-Aragó et al.: "Mitochondrial bioenergetics and dynamics interplay in complex I-deficient fibroblasts." in: Biochimica et biophysica acta, Vol. 1802, Issue 5, pp. 443-53, 2010 (PubMed).

Hosts (24), (3)
Reactivities (28), (13), (13), (12)
Applications (14), (14), (10), (4), (1), (1), (1), (1)
Conjugates (3), (3), (3), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (2), (2), (1), (1)
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