Adaptor-Related Protein Complex 1, sigma 2 Subunit (AP1S2) antibody

Details for Product No. ABIN395874
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Synonyms MGC:1902, MRX59, MRXS21, MRXSF, SIGMA1B, EST1, AI853648, 1500012A13Rik, AP1S1, RGD1561862, zgc:65824, zgc:77925, wu:fb94g06, wu:fd19a08, AP1S2
(3), (2)
Clonality (Clone)
Monoclonal ()
(4), (2), (1), (1)
Pubmed 5 references available
Catalog no. ABIN395874
Quantity 0.1 mg
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Immunogen AP1S2 (AAH01117, 1 a.a. ~ 158 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 3B9-G5
Isotype IgG2b kappa
Specificity AP1S2 (AAH01117, 1 a.a. ~ 158 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name AP1S2
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 18615 DA
Gene ID 12406
Research Area Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml

Background: Adaptor protein complex 1 is found at the cytoplasmic face of coated vesicles located at the Golgi complex, where it mediates both the recruitment of clathrin to the membrane and the recognition of sorting signals within the cytosolic tails of transmembrane receptors. This complex is a heterotetramer composed of two large, one medium, and one small adaptin subunit. The protein encoded by this gene serves as the small subunit of this complex and is a member of the adaptin protein family. Transcript variants utilizing alternative polyadenylation signals exist for this gene.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Adaptor-Related Protein Complex 1, sigma 2 Subunit (AP1S2) antibody Detection limit for recombinant GST tagged AP1S2 is approximately 3 ng/mL as a capture antibody.
Background publications Coleman, Van Damme, Day et al.: "Leucine-specific, functional interactions between human immunodeficiency virus type 1 Nef and adaptor protein complexes." in: Journal of virology, Vol. 79, Issue 4, pp. 2066-78, 2005 (PubMed).

Coleman, Hitchin, Noviello et al.: "HIV-1 Nef stabilizes AP-1 on membranes without inducing ARF1-independent de novo attachment." in: Virology, Vol. 345, Issue 1, pp. 148-55, 2006 (PubMed).

Tarpey, Stevens, Teague et al.: "Mutations in the gene encoding the Sigma 2 subunit of the adaptor protein 1 complex, AP1S2, cause X-linked mental retardation." in: American journal of human genetics, Vol. 79, Issue 6, pp. 1119-24, 2006 (PubMed).

Saillour, Zanni, Des Portes et al.: "Mutations in the AP1S2 gene encoding the sigma 2 subunit of the adaptor protein 1 complex are associated with syndromic X-linked mental retardation with hydrocephalus and calcifications in basal ganglia." in: Journal of medical genetics, Vol. 44, Issue 11, pp. 739-44, 2007 (PubMed).

Borck, Mollà-Herman, Boddaert et al.: "Clinical, cellular, and neuropathological consequences of AP1S2 mutations: further delineation of a recognizable X-linked mental retardation syndrome." in: Human mutation, Vol. 29, Issue 7, pp. 966-74, 2008 (PubMed).

Hosts (3), (2)
Reactivities (5)
Applications (4), (2), (1), (1)
Epitopes (2), (1)
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