Tafazzin (TAZ) (Met19) antibody

Antigen: Tafazzin (TAZ)

Synonyms: EFE, BTHS, EFE2, G4.5, Taz1, CMD3A, LVNCX, XAP-2, FLJ27390, AW107266, AW552613, 5031411C02Rik, 9130012G04Rik, MGC91803, zgc:91803, wu:fb39f12, MGC116399, MGC54019, TAZ, taz, GB11956, DKFZp586I1419, Taz, C78399, 2310058J06Rik, 2610021I22Rik

Binding Site: Met19

Clonality: Monoclonal (3C10)

Host: Mouse

Reactivity: Human

Application: ELISA

Certificates: ISO 9001:2008

Catalog no.: ABIN395886

Additional Information

Alternative name: TAZ

Gene ID: 6901

Immunogen: TAZ (AAH11515, 1 a.a. ~ 263 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K

Isotype: IgG2a kappa

Clone: 3C10

Description: Other names: BTHS, CMD3A, EFE, EFE2, G4.5, LVNCX, XAP2 tafazzin (cardiomyopathy, dilated 3A (X-linked), endocardial fibroelastosis 2, Barth syndrome)

Characteristics: Purified Mouse Monoclonal Antibody (Mab)

Specificity: TAZ (AAH11515, 1 a.a. ~ 263 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Molecular Weight: NONE?! DA

Comments:

Background: This gene encodes a protein that is expressed at high levels in cardiac and skeletal muscle. Mutations in this gene have been associated with a number of clinical disorders including Barth syndrome, dilated cardiomyopathy (DCM), hypertrophic DCM, endocardial fibroelastosis, and left ventricular noncompaction (LVNC). Multiple transcript variants encoding different isoforms have been described. A long form and a short form of each of these isoforms is produced, the short form lacks a hydrophobic leader sequence and may exist as a cytoplasmic protein rather than being membrane-bound. Other alternatively spliced transcripts have been described but the full-length nature of all these transcripts is not known.

Synonyms: EFE, BTHS, EFE2, G4.5, Taz1, CMD3A, LVNCX, XAP-2, FLJ27390, AW107266, AW552613, 5031411C02Rik, 9130012G04Rik, MGC91803, zgc:91803, wu:fb39f12, MGC116399, MGC54019, TAZ, taz, GB11956, DKFZp586I1419, Taz, C78399, 2310058J06Rik, 2610021I22Rik

Application Details

Application Notes: ELISA ~~ 1ug/ml~3ng/ml

Purification: Purified

Buffer: Clear, colorless solution in phosphate buffered saline, pH 7.2 .

Storage: Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles

Research Area: Cell Structure

Restrictions: For Research Use only

Images

Detection limit for recombinant GST tagged TAZ is approximately 10ng/ml as a capture antibody.

Publications

Product: Zhang, Liu, Zha et al.: "TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition." in: The Journal of biological chemistry, Vol. 284, Issue 20, pp. 13355-62, 2009 (PubMed).

Ferrara, De Sanctis, Rossi et al.: "Mutations in TAZ/WWTR1, a co-activator of NKX2.1 and PAX8 are not a frequent cause of thyroid dysgenesis." in: Journal of endocrinological investigation, Vol. 32, Issue 3, pp. 238-41, 2009 (PubMed).

Xu, Zhang, Malhotra et al.: "Characterization of tafazzin splice variants from humans and fruit flies." in: The Journal of biological chemistry, Vol. 284, Issue 42, pp. 29230-9, 2009 (PubMed).

Strakova, Reed, Ihnatovych: "Human transcriptional coactivator with PDZ-binding motif (TAZ) is downregulated during decidualization." in: Biology of reproduction, Vol. 82, Issue 6, pp. 1112-8, 2010 (PubMed).

Zimmerman, Cox, Lakdawala et al.: "A novel custom resequencing array for dilated cardiomyopathy." in: Genetics in medicine : official journal of the American College of Medical Genetics, Vol. 12, Issue 5, pp. 268-78, 2010 (PubMed).