Hydroxyacyl-CoA Dehydrogenase (HADH) (AA 205-315) antibody

Details for Product No. ABIN395923
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Antigen
Synonyms HADHSC, hadhsc, HADH, HAD, HADH1, HCDH, HHF4, MSCHAD, SCHAD, Hadhsc, AA409008, AU019341, AW742602, Schad, wu:fb66a11, zgc:86777
Epitope
AA 205-315
(9), (3), (3), (3), (2), (2), (1), (1), (1)
Reactivity
Human
(63), (49), (45), (34), (15), (13), (1), (1), (1)
Host
Mouse
(67), (13), (5), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(7), (4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (1), (1), (1)
Application
Western Blotting (WB)
(57), (30), (26), (16), (15), (14), (12), (10), (6), (3), (3), (3), (3)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN395923
450.00 $
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  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen HADHSC (NP_005318, 205 a.a. ~ 315 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 3C9
Isotype IgG3 kappa
Specificity HADHSC (NP_005318, 205 a.a. ~ 315 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name HADHSC
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 34278 DA
Gene ID 12406
NCBI Accession NP_005318
Research Area Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: This gene is a member of the 3-hydroxyacyl-CoA dehydrogenase gene family. The encoded protein functions in the mitochondrial matrix to catalyze the oxidation of straight-chain 3-hydroxyacyl-CoAs as part of the beta-oxidation pathway. Its enzymatic activity is highest with medium-chain-length fatty acids. Mutations in this gene cause one form of familial hyperinsulinemic hypoglycemia. The human genome contains a related pseudogene of this gene on chromosome 15.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Hydroxyacyl-CoA Dehydrogenase (HADH) (AA 205-315) antibody HADHSC monoclonal antibody (M02), clone 3C9. Western Blot analysis of HADHSC expression in HepG2.
Background publications Yang, He, Schulz: "3-Hydroxyacyl-CoA dehydrogenase and short chain 3-hydroxyacyl-CoA dehydrogenase in human health and disease." in: The FEBS journal, Vol. 272, Issue 19, pp. 4874-83, 2005 (PubMed).

Talmud, Drenos, Shah et al.: "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes." in: Genome research, Vol. 16, Issue 1, pp. 55-65, 2006 (PubMed).

van Hove, Hansen, Dekker et al.: "The HADHSC gene encoding short-chain L-3-hydroxyacyl-CoA dehydrogenase (SCHAD) and type 2 diabetes susceptibility: the DAMAGE study." in: Diabetes, Vol. 55, Issue 11, pp. 3193-6, 2006 (PubMed).

Di Candia, Gessi, Pepe et al.: "Identification of a diffuse form of hyperinsulinemic hypoglycemia by 18-fluoro-L-3,4 dihydroxyphenylalanine positron emission tomography/CT in a patient carrying a novel mutation of the HADH gene." in: European journal of endocrinology / European Federation of Endocrine Societies, Vol. 160, Issue 6, pp. 1019-23, 2009 (PubMed).

Kalsi, Kuo, Aliev et al.: "A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts." in: Human molecular genetics, Vol. 19, Issue 12, pp. 2497-506, 2010 (PubMed).

Validation Images
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