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Details for Product No. ABIN395929

Rap Guanine Nucleotide Exchange Factor (GEF) 1 (RAPGEF1) antibody

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Synonyms C3G, GRF2, Grf2, 4932418O06Rik, C3G-1, C3G-2, C3g, rapgef1, zgc:56372, C(3)G, CG14436, CG3126, CG42328, DC3-G, DC3G, Dmel\\CG42328, Dmel_CG14436, Dmel_CG3126, c(3)G, RAPGEF1
»Alternatives Human
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
»Alternatives ELISA, Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN395929
Quantity 0.1 mg
450.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen RAPGEF1 (AAH41710, 1 a.a. ~ 110 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 3D10
Isotype IgG2a kappa
Specificity RAPGEF1 (AAH41710, 1 a.a. ~ 110 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name RAPGEF1
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 120548 DA
Gene ID 12406
Research Area Cell Signaling, Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000

Background: This gene encodes a human guanine nucleotide exchange factor. It transduces signals from CRK by binding the SH3 domain of CRK, and activating several members of the Ras family of GTPases. This signaling cascade that may be involved in apoptosis, integrin-mediated signal transduction, and cell transformation. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Maia, Sanz, Gutierrez-Berzal et al.: "C3G silencing enhances STI-571-induced apoptosis in CML cells through p38 MAPK activation, but it antagonizes STI-571 inhibitory effect on survival." in: Cellular signalling, Vol. 21, Issue 7, pp. 1229-35, 2009 (PubMed).

Schönherr, Yang, Vigny et al.: "Anaplastic lymphoma kinase activates the small GTPase Rap1 via the Rap1-specific GEF C3G in both neuroblastoma and PC12 cells." in: Oncogene, Vol. 29, Issue 19, pp. 2817-30, 2010 (PubMed).

Rose, Behm, Drgon et al.: "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score." in: Molecular medicine (Cambridge, Mass.), Vol. 16, Issue 7-8, pp. 247-53, 2010 (PubMed).

Ban, Heo, Oh et al.: "Identification of type 2 diabetes-associated combination of SNPs using support vector machine." in: BMC genetics, Vol. 11, pp. 26, 2010 (PubMed).

Mitra, Radha: "F-actin-binding domain of c-Abl regulates localized phosphorylation of C3G: role of C3G in c-Abl-mediated cell death." in: Oncogene, Vol. 29, Issue 32, pp. 4528-42, 2010 (PubMed).

Alternatives for antigen "Rap Guanine Nucleotide Exchange Factor (GEF) 1 (RAPGEF1)", type "Antibodies"
Hosts (14), (3), (1)
Reactivities (17), (1), (1), (1), (1), (1)
Applications (13), (12), (3), (3), (1), (1), (1)
Epitopes (5), (2), (2), (1), (1)